Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0091) | |||||
|---|---|---|---|---|---|
| DME Name | Prostaglandin G/H synthase 1 (COX-1), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 1.14.99.1 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Third ventricle chordoid glioma | Moderate hypermethylation | |||
| Interaction Name | DNMT-COX-1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 9.77E-03; delta-beta: 2.37E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the COX-1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 1. As a result, the interaction between DNMT and COX-1 can moderatly affect the drug-metabolizing process of Prostaglandin G/H synthase 1. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| ICD-11: 2B30 Lymphoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lymphoma | Significant hypomethylation | |||
| Interaction Name | DNMT-COX-1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 6.23E-07; delta-beta: -3.85E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the COX-1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 1. As a result, the interaction between DNMT and COX-1 can significantly affect the drug-metabolizing process of Prostaglandin G/H synthase 1. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B60 Squamous cell carcinoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Squamous cell carcinoma | Significant hypomethylation | |||
| Interaction Name | DNMT-COX-1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 2.83E-07; delta-beta: -3.52E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the COX-1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 1. As a result, the interaction between DNMT and COX-1 can significantly affect the drug-metabolizing process of Prostaglandin G/H synthase 1. | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Significant hypomethylation p-value: 1.07E-06; delta-beta: -3.39E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the COX-1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 1. As a result, the interaction between DNMT and COX-1 can significantly affect the drug-metabolizing process of Prostaglandin G/H synthase 1. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C30 Melanoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Melanoma | Significant hypomethylation | |||
| Interaction Name | DNMT-COX-1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 6.56E-03; delta-beta: -3.35E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the COX-1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 1. As a result, the interaction between DNMT and COX-1 can significantly affect the drug-metabolizing process of Prostaglandin G/H synthase 1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C77 Cervical cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| Transcription-factor regulation | |||||
| Krueppel-like factor 10 (KLF10) | Cervical cancer | Activation | |||
| Uniprot ID | |||||
| Interaction Name | KLF10-PTGS1 interaction | [1] | |||
| Studied Cell Lines | Human A549, HeLa and mouse bEnd.3 cell lines | ||||
| Ensembl ID | |||||
| Description | Krueppel-like factor 10 (KLF10) is reported to activate the transcription of COX1 gene, which leads to an increased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 1. As a result, the interaction between KLF10 and COX1 can activate the drug-metabolizing process of Prostaglandin G/H synthase 1. | ||||
| ICD-11: 2C82 Prostate cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer | Significant hypermethylation | |||
| Interaction Name | DNMT-COX-1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 6.86E-03; delta-beta: 4.62E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the COX-1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 1. As a result, the interaction between DNMT and COX-1 can significantly affect the drug-metabolizing process of Prostaglandin G/H synthase 1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C90 Renal cell carcinoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Renal cell carcinoma | Significant hypermethylation | |||
| Interaction Name | DNMT-COX-1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Other Disease Section | Significant hypermethylation p-value: 1.16E-03; delta-beta: 2.67E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the COX-1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 1. As a result, the interaction between DNMT and COX-1 can significantly affect the drug-metabolizing process of Prostaglandin G/H synthase 1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
DME methylation in tissue other than the diseased tissue of patients
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 12 Respiratory system diseases | |||||
| ICD-11: CB03 Idiopathic pulmonary fibrosis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Idiopathic pulmonary fibrosis | Moderate hypomethylation | |||
| Interaction Name | DNMT-COX-1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 8.02E-03; delta-beta: -2.04E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the COX-1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 1. As a result, the interaction between DNMT and COX-1 can moderatly affect the drug-metabolizing process of Prostaglandin G/H synthase 1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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