Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0092) | |||||
|---|---|---|---|---|---|
| DME Name | Thymidine phosphorylase (TYMP), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 2.4.2.4 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-TYMP interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.48E-16; delta-beta: -2.07E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the TYMP gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Thymidine phosphorylase. As a result, the interaction between DNMT and TYMP can moderatly affect the drug-metabolizing process of Thymidine phosphorylase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| ICD-11: 2D50 Brain cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Esthesioneuroblastoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-TYMP interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.12E-14; delta-beta: -2.70E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the TYMP gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Thymidine phosphorylase. As a result, the interaction between DNMT and TYMP can moderatly affect the drug-metabolizing process of Thymidine phosphorylase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2F37 Endocrine gland cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Pituitary adenoma | Moderate hypermethylation | |||
| Interaction Name | DNMT-TYMP interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 3.56E-03; delta-beta: 2.07E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the TYMP gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Thymidine phosphorylase. As a result, the interaction between DNMT and TYMP can moderatly affect the drug-metabolizing process of Thymidine phosphorylase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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