Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0094) | |||||
|---|---|---|---|---|---|
| DME Name | Metallothionein-1A (MT1A), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 1.8.5.1 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 11 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Glioblastoma | Significant hypermethylation | |||
| Interaction Name | DNMT-MT1A interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 2.01E-05; delta-beta: 3.25E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the MT1A gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Metallothionein-1A. As a result, the interaction between DNMT and MT1A can significantly affect the drug-metabolizing process of Metallothionein-1A. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Anaplastic pilocytic astrocytoma | Moderate hypermethylation | |||
| Interaction Name | DNMT-MT1A interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 1.02E-11; delta-beta: 2.81E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the MT1A gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Metallothionein-1A. As a result, the interaction between DNMT and MT1A can moderatly affect the drug-metabolizing process of Metallothionein-1A. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Malignant astrocytoma | Significant hypermethylation | |||
| Interaction Name | DNMT-MT1A interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 5.02E-37; delta-beta: 3.16E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the MT1A gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Metallothionein-1A. As a result, the interaction between DNMT and MT1A can significantly affect the drug-metabolizing process of Metallothionein-1A. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Brain neuroepithelial tumour | Significant hypermethylation | |||
| Interaction Name | DNMT-MT1A interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 3.29E-12; delta-beta: 3.12E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the MT1A gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Metallothionein-1A. As a result, the interaction between DNMT and MT1A can significantly affect the drug-metabolizing process of Metallothionein-1A. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Oligodendroglial tumour | Significant hypermethylation | |||
| Interaction Name | DNMT-MT1A interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.16E-04; delta-beta: 3.85E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the MT1A gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Metallothionein-1A. As a result, the interaction between DNMT and MT1A can significantly affect the drug-metabolizing process of Metallothionein-1A. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Melanocytoma | Moderate hypermethylation | |||
| Interaction Name | DNMT-MT1A interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 1.63E-03; delta-beta: 2.24E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the MT1A gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Metallothionein-1A. As a result, the interaction between DNMT and MT1A can moderatly affect the drug-metabolizing process of Metallothionein-1A. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Multilayered rosettes embryonal tumour | Significant hypermethylation | |||
| Interaction Name | DNMT-MT1A interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 4.33E-09; delta-beta: 3.23E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the MT1A gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Metallothionein-1A. As a result, the interaction between DNMT and MT1A can significantly affect the drug-metabolizing process of Metallothionein-1A. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Diffuse midline glioma | Significant hypermethylation | |||
| Interaction Name | DNMT-MT1A interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 2.73E-39; delta-beta: 3.21E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the MT1A gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Metallothionein-1A. As a result, the interaction between DNMT and MT1A can significantly affect the drug-metabolizing process of Metallothionein-1A. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Oligodendroglioma | Significant hypermethylation | |||
| Interaction Name | DNMT-MT1A interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 9.69E-32; delta-beta: 4.67E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the MT1A gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Metallothionein-1A. As a result, the interaction between DNMT and MT1A can significantly affect the drug-metabolizing process of Metallothionein-1A. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Atypical teratoid/rhabdoid tumour | Significant hypermethylation | |||
| Interaction Name | DNMT-MT1A interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 5.22E-12; delta-beta: 4.01E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the MT1A gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Metallothionein-1A. As a result, the interaction between DNMT and MT1A can significantly affect the drug-metabolizing process of Metallothionein-1A. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Anaplastic pleomorphic xanthoastrocytoma | Significant hypermethylation | |||
| Interaction Name | DNMT-MT1A interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.86E-05; delta-beta: 3.35E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the MT1A gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Metallothionein-1A. As a result, the interaction between DNMT and MT1A can significantly affect the drug-metabolizing process of Metallothionein-1A. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B30 Lymphoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lymphoma | Significant hypermethylation | |||
| Interaction Name | DNMT-MT1A interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 4.63E-27; delta-beta: 4.72E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the MT1A gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Metallothionein-1A. As a result, the interaction between DNMT and MT1A can significantly affect the drug-metabolizing process of Metallothionein-1A. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C25 Lung cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lung cancer | Significant hypermethylation | |||
| Interaction Name | DNMT-MT1A interaction | ||||
| The Methylation Level of Disease Section Compare with the Other Disease Section | Significant hypermethylation p-value: 5.66E-04; delta-beta: 8.59E-02 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the MT1A gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Metallothionein-1A. As a result, the interaction between DNMT and MT1A can significantly affect the drug-metabolizing process of Metallothionein-1A. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
DME methylation in tissue other than the diseased tissue of patients
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C30 Melanoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Melanoma | Significant hypermethylation | |||
| Interaction Name | DNMT-MT1A interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 2.85E-09; delta-beta: 3.67E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the MT1A gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Metallothionein-1A. As a result, the interaction between DNMT and MT1A can significantly affect the drug-metabolizing process of Metallothionein-1A. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C82 Prostate cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer | Significant hypermethylation | |||
| Interaction Name | DNMT-MT1A interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 9.57E-08; delta-beta: 3.12E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the MT1A gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Metallothionein-1A. As a result, the interaction between DNMT and MT1A can significantly affect the drug-metabolizing process of Metallothionein-1A. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2D50 Brain cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Esthesioneuroblastoma | Moderate hypermethylation | |||
| Interaction Name | DNMT-MT1A interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 9.39E-07; delta-beta: 2.61E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the MT1A gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Metallothionein-1A. As a result, the interaction between DNMT and MT1A can moderatly affect the drug-metabolizing process of Metallothionein-1A. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2E06 Prostate cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer metastasis | Significant hypermethylation | |||
| Interaction Name | DNMT-MT1A interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.01E-06; delta-beta: 3.62E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the MT1A gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Metallothionein-1A. As a result, the interaction between DNMT and MT1A can significantly affect the drug-metabolizing process of Metallothionein-1A. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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