| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification 04 Immune system diseases |
| ICD-11: 4A44 Vasculitis |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Transcription-factor regulation |
| Transcription factor Sp1 (SP1) |
Vasculitis |
Activation |
| Uniprot ID |
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| Interaction Name |
SP1-MPO interaction |
[1], [2] |
| Studied Cell Lines |
ANCA-associated vasculitis cell line |
| Ensembl ID |
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| Description |
Transcription factor Sp1 (SP1) is reported to activate the transcription of MPO gene, which leads to an increased expression of the drug-metabolizing enzyme Myeloperoxidase. As a result, the interaction between SP1 and MPO can activate the drug-metabolizing process of Myeloperoxidase. |
| ICD Disease Classification 08 Nervous system diseases |
| ICD-11: 8E40 Systemic vasculitides |
Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
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| Oligomerization |
| Ceruloplasmin (CP) |
Systemic vasculitides |
Heterotrimer |
| Uniprot ID |
|
| Interaction Name |
CP, LTF and MPO heterotrimerization |
[3] |
| Studied Cell Lines |
Healthy subjects |
| Description |
Ceruloplasmin (CP) and Lactotransferrin (LTF) is reported to heterotrimerize with the MPO protein, which leads to a suppressed activity of the drug-metabolizing enzyme Myeloperoxidase. As a result, the interaction among CP, LTF and MPO can inhibit the drug-metabolizing process of Myeloperoxidase. |
| Lactotransferrin (LTF) |
Systemic vasculitides |
Heterotrimer |
| Uniprot ID |
|
| Interaction Name |
LTF, CP and MPO heterotrimerization |
[3] |
| Studied Cell Lines |
Healthy subjects |
| Description |
Lactotransferrin (LTF) and Ceruloplasmin (CP) is reported to heterotrimerize with the MPO protein, which leads to a suppressed activity of the drug-metabolizing enzyme Myeloperoxidase. As a result, the interaction among LTF, CP and MPO can inhibit the drug-metabolizing process of Myeloperoxidase. |
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