Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0097)
DME Name	Quinone reductase 1 (NQO1), Homo sapiens	DME Info
UniProt ID	NQO1_HUMAN
EC Number	EC: 1.6.5.2 (Click to Show/Hide the Complete EC Tree) Oxidoreductase NADH/NADPH oxidoreductase Quinone acceptor oxidoreductase EC: 1.6.5.2
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
ICD Disease Classification Healthy
ICD-11: Healthy		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Histone modification
Histone deacetylases (HDACs)		Health		Repression
Uniprot ID	HDAC1_HUMAN
Interaction Name	HDACs-NQO1 interaction				[1]
Studied Cell Lines	Retinal tissues
Description	Histone deacetylases (HDACs) are reported to deacetylate the NQO1 gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme Quinone reductase 1. As a result, the interaction between HDACs and NQO1 can inhibit the drug-metabolizing process of Quinone reductase 1.
ICD Disease Classification 02 Neoplasms
ICD-11: 2A00 Brain cancer		Click to Show/Hide the Full List of HOSPPI: 4 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Brain neuroblastoma		Significant hypomethylation
Interaction Name	DNMT-NQO1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 1.00E-29; delta-beta: -4.40E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the NQO1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Quinone reductase 1. As a result, the interaction between DNMT and NQO1 can significantly affect the drug-metabolizing process of Quinone reductase 1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Melanocytoma		Significant hypomethylation
Interaction Name	DNMT-NQO1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 3.84E-12; delta-beta: -5.32E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the NQO1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Quinone reductase 1. As a result, the interaction between DNMT and NQO1 can significantly affect the drug-metabolizing process of Quinone reductase 1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Multilayered rosettes embryonal tumour		Moderate hypomethylation
Interaction Name	DNMT-NQO1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 6.72E-24; delta-beta: -2.71E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the NQO1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Quinone reductase 1. As a result, the interaction between DNMT and NQO1 can moderatly affect the drug-metabolizing process of Quinone reductase 1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Diffuse midline glioma		Moderate hypomethylation
Interaction Name	DNMT-NQO1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 6.49E-27; delta-beta: -2.33E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the NQO1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Quinone reductase 1. As a result, the interaction between DNMT and NQO1 can moderatly affect the drug-metabolizing process of Quinone reductase 1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2B71 Gastric cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Gastric cancer		Significant hypomethylation
Interaction Name	DNMT-NQO1 interaction
The Methylation Level of Disease Section Compare with the Adjacent Tissue	Significant hypomethylation p-value: 6.26E-03; delta-beta: -5.09E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the NQO1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Quinone reductase 1. As a result, the interaction between DNMT and NQO1 can significantly affect the drug-metabolizing process of Quinone reductase 1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue adjacent to the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data of patients in the normal section of the tissue adjacent to the disease section Download DME methylation data in the tissue of healthy individual
ICD-11: 2C12 Liver cancer		Click to Show/Hide the Full List of HOSPPI: 3 HOSPPI
Transcription-factor regulation
NFE2-related factor 1 (NFE2L1)		Liver cancer		Activation
Uniprot ID	NF2L1_HUMAN
Interaction Name	NFE2L1-NQO1 interaction				[2]
Studied Cell Lines	HepG2 cell line
Ensembl ID	ENSG00000082641
Description	NFE2-related factor 1 (NFE2L1) is reported to activate the transcription of NQO1 gene, which leads to an increased expression of the drug-metabolizing enzyme Quinone reductase 1. As a result, the interaction between NFE2L1 and NQO1 can activate the drug-metabolizing process of Quinone reductase 1.
NFE2-related factor 2 (NFE2L2)		Liver cancer		Activation
Uniprot ID	NF2L2_HUMAN
Interaction Name	NFE2L2-NQO1 interaction				[2]
Studied Cell Lines	HepG2 cell line
Ensembl ID	ENSG00000116044
Description	NFE2-related factor 2 (NFE2L2) is reported to activate the transcription of NQO1 gene, which leads to an increased expression of the drug-metabolizing enzyme Quinone reductase 1. As a result, the interaction between NFE2L2 and NQO1 can activate the drug-metabolizing process of Quinone reductase 1.
DNA methylation
DNA methyltransferase (DNMT)		Liver cancer		Moderate hypomethylation
Interaction Name	DNMT-NQO1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 2.92E-02; delta-beta: -2.34E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the NQO1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Quinone reductase 1. As a result, the interaction between DNMT and NQO1 can moderatly affect the drug-metabolizing process of Quinone reductase 1.
The Methylation Level of Disease Section Compare with the Adjacent Tissue	Moderate hypomethylation p-value: 2.48E-12; delta-beta: -2.49E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the NQO1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Quinone reductase 1. As a result, the interaction between DNMT and NQO1 can moderatly affect the drug-metabolizing process of Quinone reductase 1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue adjacent to the diseased tissue of patients DME methylation in the normal tissue of healthy individuals DME methylation in tissue other than the diseased tissue of patients
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data of patients in the normal section of the tissue adjacent to the disease section Download DME methylation data in the tissue of healthy individual Download DME methylation data in the tissue of the other disease section
ICD-11: 2C25 Lung cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Lung cancer		Significant hypomethylation
Interaction Name	DNMT-NQO1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 1.91E-20; delta-beta: -3.11E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the NQO1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Quinone reductase 1. As a result, the interaction between DNMT and NQO1 can significantly affect the drug-metabolizing process of Quinone reductase 1.
The Methylation Level of Disease Section Compare with the Other Disease Section	Significant hypomethylation p-value: 6.90E-09; delta-beta: -3.44E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the NQO1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Quinone reductase 1. As a result, the interaction between DNMT and NQO1 can significantly affect the drug-metabolizing process of Quinone reductase 1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals DME methylation in tissue other than the diseased tissue of patients
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual Download DME methylation data in the tissue of the other disease section
ICD-11: 2C30 Melanoma		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Melanoma		Significant hypomethylation
Interaction Name	DNMT-NQO1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 1.08E-07; delta-beta: -5.32E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the NQO1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Quinone reductase 1. As a result, the interaction between DNMT and NQO1 can significantly affect the drug-metabolizing process of Quinone reductase 1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2C60 Breast cancer		Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
Transcription-factor regulation
Estrogen receptor (ESR1)		Breast cancer		Repression
Uniprot ID	ESR1_HUMAN
Interaction Name	ESR1-NQO1 interaction				[3]
Studied Cell Lines	MCF-7, T47D and MDA-MB-231 cell lines
Ensembl ID	ENSG00000091831
Description	Estrogen receptor (ESR1) is reported to repress the transcription of NQO1 gene, which leads to a decreased expression of the drug-metabolizing enzyme Quinone reductase 1. As a result, the interaction between ESR1 and NQO1 can repress the drug-metabolizing process of Quinone reductase 1.
SIR2-like protein 1 (SIRT1)		Breast cancer		Repression
Uniprot ID	SIR1_HUMAN
Interaction Name	SIRT1-NQO1 interaction				[3]
Studied Cell Lines	MCF-7, T47D and MDA-MB-231 cell lines
Description	SIR2-like protein 1 (SIRT1) is reported to repress the transcription of NQO1 gene, which leads to a decreased expression of the drug-metabolizing enzyme Quinone reductase 1. As a result, the interaction between SIRT1 and NQO1 can repress the drug-metabolizing process of Quinone reductase 1.

References
1	Nuclear Factor (Erythroid-Derived 2)-Like 2 (Nrf2) Contributes to the Neuroprotective Effects of Histone Deacetylase Inhibitors In Retinal Ischemia-Reperfusion Injury. Neuroscience. 2019 Oct 15;418:25-36.
2	Small maf (MafG and MafK) proteins negatively regulate antioxidant response element-mediated expression and antioxidant induction of the NAD(P)H:Quinone oxidoreductase1 gene. J Biol Chem. 2000 Dec 22;275(51):40134-41.
3	Inhibition of estrogen signaling activates the NRF2 pathway in breast cancer. Breast Cancer Res Treat. 2010 Nov;124(2):585-91.

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