Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0099)
DME Name Cholesterol desmolase (CYP11A1), Homo sapiens DME Info
UniProt ID
CP11A_HUMAN
EC Number    EC: 1.14.15.6     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Iron-sulfur protein donor oxidoreductase
EC: 1.14.15.6
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification Healthy
               ICD-11: Healthy Click to Show/Hide the Full List of HOSPPI:        6 HOSPPI
                     Oligomerization
                            Cytochrome b5 (CYB5A) Health Heterodimer
Uniprot ID
CYB5_HUMAN
Interaction Name CYB5A-CYP11A1 heterodimerization [1]
Studied Cell Lines Escherichia coli cell line
Description Cytochrome b5 (CYB5A) is reported to heterodimerize with the CYP11A1 protein, which has no effect on the enzyme activity of Cholesterol desmolase. As a result, the interaction between CYB5A and CYP11A1 can have no effect on the drug-metabolizing process of Cholesterol desmolase.
                     Transcription-factor regulation
                            Erythroid TF factor (GATA1) Health Activation
Uniprot ID
GATA1_HUMAN
Interaction Name GATA1-CYP11A1 interaction [2]
Studied Cell Lines Adrenal cortex and testicular Leydig cell line
Description Erythroid TF factor (GATA1) is reported to activate the transcription of CYP11A1 gene, which leads to an increased expression of the drug-metabolizing enzyme Cholesterol desmolase. As a result, the interaction between GATA1 and CYP11A1 can activate the drug-metabolizing process of Cholesterol desmolase.
                            Lipopolysaccharide-binding (LBP) Health Activation
Uniprot ID
LBP_HUMAN
Interaction Name LBP-CYP11A1 interaction [2]
Studied Cell Lines Adrenal cortex and testicular Leydig cell line
Description Lipopolysaccharide-binding (LBP) is reported to activate the transcription of CYP11A1 gene, which leads to an increased expression of the drug-metabolizing enzyme Cholesterol desmolase. As a result, the interaction between LBP and CYP11A1 can activate the drug-metabolizing process of Cholesterol desmolase.
                            Nuclear receptor family 0 B1 (NR0B1) Health Activation
Uniprot ID
NR0B1_HUMAN
Interaction Name NR0B1-CYP11A1 interaction [2]
Studied Cell Lines Adrenal cortex and testicular Leydig cell line
Description Nuclear receptor family 0 B1 (NR0B1) is reported to activate the transcription of CYP11A1 gene, which leads to an increased expression of the drug-metabolizing enzyme Cholesterol desmolase. As a result, the interaction between NR0B1 and CYP11A1 can activate the drug-metabolizing process of Cholesterol desmolase.
                            Steroidogenic factor 1 (NR5A1) Health Activation
Uniprot ID
STF1_HUMAN
Interaction Name NR5A1-CYP11A1 interaction [2]
Studied Cell Lines Adrenal cortex and testicular Leydig cell line
Description Steroidogenic factor 1 (NR5A1) is reported to activate the transcription of CYP11A1 gene, which leads to an increased expression of the drug-metabolizing enzyme Cholesterol desmolase. As a result, the interaction between NR5A1 and CYP11A1 can activate the drug-metabolizing process of Cholesterol desmolase.
                            Zinc finger protein rapa (TRERF1) Health Activation
Uniprot ID
TREF1_HUMAN
Interaction Name TRERF1-CYP11A1 interaction [2]
Studied Cell Lines Adrenal cortex and testicular Leydig cell line
Description Zinc finger protein rapa (TRERF1) is reported to activate the transcription of CYP11A1 gene, which leads to an increased expression of the drug-metabolizing enzyme Cholesterol desmolase. As a result, the interaction between TRERF1 and CYP11A1 can activate the drug-metabolizing process of Cholesterol desmolase.
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2A00 Brain cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Third ventricle chordoid glioma Significant hypermethylation
Interaction Name DNMT-CYP11A1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Significant hypermethylation
p-value: 7.09E-04; delta-beta: 6.58E-01
Description DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the CYP11A1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Cholesterol desmolase. As a result, the interaction between DNMT and CYP11A1 can significantly affect the drug-metabolizing process of Cholesterol desmolase.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples
Download DME methylation data of patients in the disease section of the tissue
Download DME methylation data in the tissue of healthy individual
               ICD-11: 2B30 Lymphoma Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Lymphoma Significant hypomethylation
Interaction Name DNMT-CYP11A1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Significant hypomethylation
p-value: 2.74E-11; delta-beta: -4.31E-01
Description DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the CYP11A1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cholesterol desmolase. As a result, the interaction between DNMT and CYP11A1 can significantly affect the drug-metabolizing process of Cholesterol desmolase.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples
Download DME methylation data of patients in the disease section of the tissue
Download DME methylation data in the tissue of healthy individual
               ICD-11: 2D11 Adrenocortical carcinoma Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Transcription-factor regulation
                            Splicing factor 1 (SF1) Adrenocortical carcinoma Activation
Uniprot ID
SF01_HUMAN
Interaction Name SF1-CYP11A1 interaction [3]
Studied Cell Lines Y1 adrenocortical cell line
Description Splicing factor 1 (SF1) is reported to activate the transcription of CYP11A1 gene, which leads to an increased expression of the drug-metabolizing enzyme Cholesterol desmolase. As a result, the interaction between SF1 and CYP11A1 can activate the drug-metabolizing process of Cholesterol desmolase.
      ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases
               ICD-11: 5A80 Polycystic ovary syndrome Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Transcription-factor regulation
                            TF factor GATA-6 (GATA6) Polycystic ovary syndrome Activation
Uniprot ID
GATA6_HUMAN
Interaction Name GATA6-CYP11A1 interaction [4]
Studied Cell Lines PCOS theca cell line
Ensembl ID
ENSG00000141448
Description TF factor GATA-6 (GATA6) is reported to activate the transcription of CYP11A1 gene, which leads to an increased expression of the drug-metabolizing enzyme Cholesterol desmolase. As a result, the interaction between GATA6 and CYP11A1 can activate the drug-metabolizing process of Cholesterol desmolase.
      ICD Disease Classification 16 Genitourinary system diseases
               ICD-11: GA30 Menopausal disorder Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Transcription-factor regulation
                            Forkhead box protein L2 (FOXL2) Menopausal disorder Repression
Uniprot ID
FOXL2_HUMAN
Interaction Name FOXL2-CYP11A1 interaction [5]
Studied Cell Lines CHO cell line
Ensembl ID
ENSG00000183770
Description Forkhead box protein L2 (FOXL2) is reported to repress the transcription of CYP11A1 gene, which leads to a decreased expression of the drug-metabolizing enzyme Cholesterol desmolase. As a result, the interaction between FOXL2 and CYP11A1 can repress the drug-metabolizing process of Cholesterol desmolase.
References
1 Thermodynamics of interactions between mammalian cytochromes P450 and b5. Arch Biochem Biophys. 2017 Apr 1;619:10-15.
2 Regulation of steroid production: analysis of cyp11a1 promoter. Mol Cell Endocrinol. 2011 Apr 10;336(1-2):80-4.
3 Transcriptional activation of zebrafish cyp11a1 promoter is dependent on the nuclear receptor Ff1b. J Mol Endocrinol. 2009 Sep;43(3):121-30.
4 The molecular signature of polycystic ovary syndrome (PCOS) theca cells defined by gene expression profiling. J Reprod Immunol. 2004 Aug;63(1):51-60.
5 Mutant Forkhead L2 (FOXL2) proteins associated with premature ovarian failure (POF) dimerize with wild-type FOXL2, leading to altered regulation of genes associated with granulosa cell differentiation. Endocrinology. 2011 Oct;152(10):3917-29.

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