Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0102) | |||||
|---|---|---|---|---|---|
| DME Name | Choline O-acetyltransferase (CHAT), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 2.3.1.6 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Multilayered rosettes embryonal tumour | Moderate hypomethylation | |||
| Interaction Name | DNMT-CHAT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 7.95E-12; delta-beta: -2.16E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CHAT gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Choline O-acetyltransferase. As a result, the interaction between DNMT and CHAT can moderatly affect the drug-metabolizing process of Choline O-acetyltransferase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| ICD-11: 2C12 Liver cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Liver cancer | Moderate hypomethylation | |||
| Interaction Name | DNMT-CHAT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 3.48E-05; delta-beta: -2.43E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CHAT gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Choline O-acetyltransferase. As a result, the interaction between DNMT and CHAT can moderatly affect the drug-metabolizing process of Choline O-acetyltransferase. | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Moderate hypomethylation p-value: 7.11E-11; delta-beta: -2.31E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CHAT gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Choline O-acetyltransferase. As a result, the interaction between DNMT and CHAT can moderatly affect the drug-metabolizing process of Choline O-acetyltransferase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
DME methylation in tissue other than the diseased tissue of patients
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| ICD-11: 2C90 Renal cell carcinoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Renal cell carcinoma | Significant hypermethylation | |||
| Interaction Name | DNMT-CHAT interaction | ||||
| The Methylation Level of Disease Section Compare with the Other Disease Section | Significant hypermethylation p-value: 8.76E-03; delta-beta: 4.60E-02 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the CHAT gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Choline O-acetyltransferase. As a result, the interaction between DNMT and CHAT can significantly affect the drug-metabolizing process of Choline O-acetyltransferase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
DME methylation in tissue other than the diseased tissue of patients
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases | |||||
| ICD-11: 5A61 Pituitary gland hypofunction | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Chordoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-CHAT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 5.53E-03; delta-beta: -2.18E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the CHAT gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Choline O-acetyltransferase. As a result, the interaction between DNMT and CHAT can moderatly affect the drug-metabolizing process of Choline O-acetyltransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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