Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0105) | |||||
|---|---|---|---|---|---|
| DME Name | Arylsulfatase B (ARSB), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 3.1.6.12 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 3 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-ARSB interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 2.89E-16; delta-beta: -6.56E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the ARSB gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Arylsulfatase B. As a result, the interaction between DNMT and ARSB can significantly affect the drug-metabolizing process of Arylsulfatase B. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Brain neuroepithelial tumour | Significant hypomethylation | |||
| Interaction Name | DNMT-ARSB interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.36E-16; delta-beta: -6.58E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the ARSB gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Arylsulfatase B. As a result, the interaction between DNMT and ARSB can significantly affect the drug-metabolizing process of Arylsulfatase B. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Atypical teratoid/rhabdoid tumour | Moderate hypermethylation | |||
| Interaction Name | DNMT-ARSB interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 7.00E-09; delta-beta: 2.39E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the ARSB gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Arylsulfatase B. As a result, the interaction between DNMT and ARSB can moderatly affect the drug-metabolizing process of Arylsulfatase B. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B5F Uterine carcinosarcoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Uterine carcinosarcoma | Significant hypermethylation | |||
| Interaction Name | DNMT-ARSB interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.49E-03; delta-beta: 4.51E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the ARSB gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Arylsulfatase B. As a result, the interaction between DNMT and ARSB can significantly affect the drug-metabolizing process of Arylsulfatase B. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 11 Circulatory system diseases | |||||
| ICD-11: BD51 Arterial aneurysm | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Arterial aneurysm | Significant hypermethylation | |||
| Interaction Name | DNMT-ARSB interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 9.75E-03; delta-beta: 4.62E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the ARSB gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Arylsulfatase B. As a result, the interaction between DNMT and ARSB can significantly affect the drug-metabolizing process of Arylsulfatase B. | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Significant hypermethylation p-value: 8.13E-03; delta-beta: 4.26E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the ARSB gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Arylsulfatase B. As a result, the interaction between DNMT and ARSB can significantly affect the drug-metabolizing process of Arylsulfatase B. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 12 Respiratory system diseases | |||||
| ICD-11: CA23 Asthma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Asthma | Moderate hypermethylation | |||
| Interaction Name | DNMT-ARSB interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 2.12E-02; delta-beta: 2.12E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the ARSB gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Arylsulfatase B. As a result, the interaction between DNMT and ARSB can moderatly affect the drug-metabolizing process of Arylsulfatase B. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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