Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0108) | |||||
|---|---|---|---|---|---|
| DME Name | Iduronate 2-sulfatase (IDS), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 3.1.6.13 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 3 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Anaplastic pilocytic astrocytoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-IDS interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.89E-06; delta-beta: -2.69E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the IDS gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Iduronate 2-sulfatase. As a result, the interaction between DNMT and IDS can moderatly affect the drug-metabolizing process of Iduronate 2-sulfatase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-IDS interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 5.70E-14; delta-beta: -3.71E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the IDS gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Iduronate 2-sulfatase. As a result, the interaction between DNMT and IDS can significantly affect the drug-metabolizing process of Iduronate 2-sulfatase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Melanocytoma | Moderate hypermethylation | |||
| Interaction Name | DNMT-IDS interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 7.77E-03; delta-beta: 2.51E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the IDS gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Iduronate 2-sulfatase. As a result, the interaction between DNMT and IDS can moderatly affect the drug-metabolizing process of Iduronate 2-sulfatase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases | |||||
| ICD-11: 5B81 Obesity | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Obesity | Moderate hypomethylation | |||
| Interaction Name | DNMT-IDS interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.37E-07; delta-beta: -2.62E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the IDS gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Iduronate 2-sulfatase. As a result, the interaction between DNMT and IDS can moderatly affect the drug-metabolizing process of Iduronate 2-sulfatase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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