Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0109)
DME Name Superoxide dismutase 1 (SOD1), Homo sapiens DME Info
UniProt ID
SODC_HUMAN
EC Number    EC: 1.15.1.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Superoxide radical acceptor oxidoreductase
Superoxide radical acceptor oxidoreductase
EC: 1.15.1.1
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification Healthy
               ICD-11: Healthy Click to Show/Hide the Full List of HOSPPI:        4 HOSPPI
                     Transcription-factor regulation
                            Homeobox protein MSX-2 (MSX2) Health Activation
Uniprot ID
MSX2_HUMAN
Interaction Name MSX2-SOD1 interaction [2]
Studied Cell Lines Healthy subjects
Ensembl ID
ENSG00000120149
Description Homeobox protein MSX-2 (MSX2) is reported to activate the transcription of SOD1 gene, which leads to an increased expression of the drug-metabolizing enzyme Superoxide dismutase 1. As a result, the interaction between MSX2 and SOD1 can activate the drug-metabolizing process of Superoxide dismutase 1.
                            PPA receptor delta (PPARD) Health Activation
Uniprot ID
PPARD_HUMAN
Interaction Name PPARD-SOD1 interaction [4]
Studied Cell Lines Human umbilical vein endothelial cell line
Ensembl ID
ENSG00000112033
Description PPA receptor delta (PPARD) is reported to activate the transcription of SOD1 gene, which leads to an increased expression of the drug-metabolizing enzyme Superoxide dismutase 1. As a result, the interaction between PPARD and SOD1 can activate the drug-metabolizing process of Superoxide dismutase 1.
                     Non-coding RNA regulation
                            hsa-miR-206 Health Suppression
miRBase ID
MIMAT0000462
Interaction Name hsa-miR-206--SOD1 regulation [3]
Studied Cell Lines Primary canine myocardial cells
Description hsa-miR-206 is reported to suppress SOD1 mRNA translation by binding to the 3' untranslated region (3'UTR) of SOD1 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Superoxide dismutase 1.
                     Histone modification
                            Histone deacetylases (HDACs) Health Repression
Uniprot ID
HDAC1_HUMAN
Interaction Name HDACs-SOD1 interaction [1]
Studied Cell Lines Human lens epithelial cells (HLECs)
Description Histone deacetylases (HDACs) are reported to deacetylate the SOD1 gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme Superoxide dismutase 1. As a result, the interaction between HDACs and SOD1 can inhibit the drug-metabolizing process of Superoxide dismutase 1.
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2C12 Liver cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Transcription-factor regulation
                            Transcription factor MTF-1 (MTF1) Liver cancer Activation
Uniprot ID
MTF1_HUMAN
Interaction Name MTF1-SOD1 interaction [5]
Studied Cell Lines HepG2 cell line
Ensembl ID
ENSG00000188786
Description Transcription factor MTF-1 (MTF1) is reported to activate the transcription of SOD1 gene, which leads to an increased expression of the drug-metabolizing enzyme Superoxide dismutase 1. As a result, the interaction between MTF1 and SOD1 can activate the drug-metabolizing process of Superoxide dismutase 1.
               ICD-11: 2C60 Breast cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Transcription-factor regulation
                            NFE2-related factor 2 (NFE2L2) Breast cancer Activation
Uniprot ID
NF2L2_HUMAN
Interaction Name NFE2L2-SOD1 interaction [6]
Studied Cell Lines MCF-7, T47D and HCC1937 cell lines
Ensembl ID
ENSG00000116044
Description NFE2-related factor 2 (NFE2L2) is reported to activate the transcription of SOD1 gene, which leads to an increased expression of the drug-metabolizing enzyme Superoxide dismutase 1. As a result, the interaction between NFE2L2 and SOD1 can activate the drug-metabolizing process of Superoxide dismutase 1.
               ICD-11: 2C77 Cervical cancer Click to Show/Hide the Full List of HOSPPI:        2 HOSPPI
                     Transcription-factor regulation
                            Early growth response 1 (EGR1) Cervical cancer Activation
Uniprot ID
EGR1_HUMAN
Interaction Name EGR1-SOD1 interaction [7]
Studied Cell Lines HeLa cell line
Ensembl ID
ENSG00000120738
Description Early growth response 1 (EGR1) is reported to activate the transcription of SOD1 gene, which leads to an increased expression of the drug-metabolizing enzyme Superoxide dismutase 1. As a result, the interaction between EGR1 and SOD1 can activate the drug-metabolizing process of Superoxide dismutase 1.
                            Transcription factor Sp1 (SP1) Cervical cancer Activation
Uniprot ID
SP1_HUMAN
Interaction Name SP1-SOD1 interaction [7], [8]
Studied Cell Lines HeLa cell line
Ensembl ID
ENSG00000185591
Description Transcription factor Sp1 (SP1) is reported to activate the transcription of SOD1 gene, which leads to an increased expression of the drug-metabolizing enzyme Superoxide dismutase 1. As a result, the interaction between SP1 and SOD1 can activate the drug-metabolizing process of Superoxide dismutase 1.
               ICD-11: 2C91 Urothelial cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Transcription-factor regulation
                            Nuclear factor NF-IL6-beta (CEBPD) Urothelial carcinoma Activation
Uniprot ID
CEBPD_HUMAN
Interaction Name CEBPD-SOD1 interaction [9]
Studied Cell Lines NTUB1 cell line
Ensembl ID
ENSG00000221869
Description Nuclear factor NF-IL6-beta (CEBPD) is reported to activate the transcription of SOD1 gene, which leads to an increased expression of the drug-metabolizing enzyme Superoxide dismutase 1. As a result, the interaction between CEBPD and SOD1 can activate the drug-metabolizing process of Superoxide dismutase 1.
      ICD Disease Classification 08 Nervous system diseases
               ICD-11: 8A00 Parkinson disease Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Transcription-factor regulation
                            Krueppel-like factor 4 (KLF4) Parkinson disease Repression
Uniprot ID
KLF4_HUMAN
Interaction Name KLF4-SOD1 interaction [10]
Studied Cell Lines M17 neuroblastoma cell line
Ensembl ID
ENSG00000136826
Description Krueppel-like factor 4 (KLF4) is reported to repress the transcription of SOD1 gene, which leads to a decreased expression of the drug-metabolizing enzyme Superoxide dismutase 1. As a result, the interaction between KLF4 and SOD1 can repress the drug-metabolizing process of Superoxide dismutase 1.
      ICD Disease Classification 16 Genitourinary system diseases
               ICD-11: GB61 Diabetic nephropathy Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Non-coding RNA regulation
                            hsa-miR-377-3p Diabetic nephropathy Suppression
miRBase ID
MIMAT0000730
Interaction Name hsa-miR-377-3p--SOD1 regulation [11]
Studied Cell Lines Human mesangial cells
Description hsa-miR-377-3p is reported to suppress SOD1 mRNA translation by binding to the 3' untranslated region (3'UTR) of SOD1 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Superoxide dismutase 1.
References
1 Evaluation of the antioxidant effects of different histone deacetylase inhibitors (HDACis) on human lens epithelial cells (HLECs) after UVB exposure. BMC Ophthalmol. 2019 Feb 4;19(1):42.
2 Is there a potential application of a fermented nutraceutical in acute respiratory illnesses? An in-vivo placebo-controlled, cross-over clinical study in different age groups of healthy subjects. J Biol Regul Homeost Agents. 2012 Apr-Jun;26(2):285-94.
3 MicroRNA profiling of atrial fibrillation in canines: miR-206 modulates intrinsic cardiac autonomic nerve remodeling by regulating SOD1. PLoS One. 2015 Mar 27;10(3):e0122674.
4 Suppression of pro-inflammatory adhesion molecules by PPAR-delta in human vascular endothelial cells. Arterioscler Thromb Vasc Biol. 2008 Feb;28(2):315-21.
5 C-terminal deletion mutant of MRE-binding transcription factor-1 Inhibits MRE-driven gene expression. J Cell Biochem. 2004 Oct 15;93(3):609-18.
6 B-cell translocation gene 2 (BTG2) stimulates cellular antioxidant defenses through the antioxidant transcription factor NFE2L2 in human mammary epithelial cells. J Biol Chem. 2012 Sep 7;287(37):31503-14.
7 The human copper-zinc superoxide dismutase gene (SOD1) proximal promoter is regulated by Sp1, Egr-1, and WT1 via non-canonical binding sites. J Biol Chem. 1999 Jan 1;274(1):503-9.
8 Sp1 and C/EBP-related factor regulate the transcription of human Cu/Zn SOD gene. Gene. 1996 Oct 31;178(1-2):177-85.
9 Transcriptional up-regulation of SOD1 by CEBPD: a potential target for cisplatin resistant human urothelial carcinoma cells. Biochem Pharmacol. 2010 Aug 1;80(3):325-34.
10 Induction of KLF4 contributes to the neurotoxicity of MPP + in M17 Cells: a new implication in parkinson's disease. J Mol Neurosci. 2013 Sep;51(1):109-17.
11 MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy. FASEB J. 2008 Dec;22(12):4126-35.

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