Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0110)
DME Name Glutathione reductase (GSR), Homo sapiens DME Info
UniProt ID
GSHR_HUMAN
EC Number    EC: 1.8.1.7     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Sulfur donor oxidoreductase
NAD/NADP acceptor oxidoreductase
EC: 1.8.1.7
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2C12 Liver cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Non-coding RNA regulation
                            hsa-miR-214-3p Liver cancer Suppression
miRBase ID
MIMAT0000271
Interaction Name hsa-miR-214-3p--GSR regulation [1]
Studied Cell Lines Bel7402 cell line
Description hsa-miR-214-3p is reported to suppress GSR mRNA translation by binding to the 3' untranslated region (3'UTR) of GSR mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Glutathione reductase.
References
1 MiR-214 promotes the alcohol-induced oxidative stress via down-regulation of glutathione reductase and cytochrome P450 oxidoreductase in liver cells. Alcohol Clin Exp Res. 2014 Jan;38(1):68-77.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.