Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0114)
DME Name	Prostaglandin G/H synthase 2 (COX-2), Homo sapiens	DME Info
UniProt ID	PGH2_HUMAN
EC Number	EC: 1.14.99.1 (Click to Show/Hide the Complete EC Tree) Oxidoreductase Oxygen paired donor oxidoreductase Oxygen paired donor oxidoreductase EC: 1.14.99.1
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
ICD Disease Classification Healthy
ICD-11: Healthy		Click to Show/Hide the Full List of HOSPPI: 16 HOSPPI
Oligomerization
Cyclooxygenase-2 (COX2)		Health		Heterodimer
Uniprot ID	PGH2_HUMAN
Interaction Name	COX2-PTGS2 heterodimerization				[2]
Studied Cell Lines	Insect cell microsomes
Affected Substrate(s):	Arachidonic acid (Metabolic product: Prostaglandin endoperoxide H(2))
Description	Cyclooxygenase-2 (COX2) is reported to heterodimerize with the COX2 protein, which leads to an increased activity of the drug-metabolizing enzyme Prostaglandin G/H synthase 2. As a result, the interaction between COX2 and COX2 can facilitate the drug-metabolizing process of Prostaglandin G/H synthase 2.
Transcription-factor regulation
AMP element-binding 1 (CREB1)		Health		Activation
Uniprot ID	CREB1_HUMAN
Interaction Name	CREB1-PTGS2 interaction				[1]
Studied Cell Lines	Human amnion fibroblast cell line
Ensembl ID	ENSG00000118260
Description	AMP element-binding 1 (CREB1) is reported to activate the transcription of COX2 gene, which leads to an increased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2. As a result, the interaction between CREB1 and COX2 can activate the drug-metabolizing process of Prostaglandin G/H synthase 2.
Early growth response 1 (EGR1)		Health		Repression
Uniprot ID	EGR1_HUMAN
Interaction Name	EGR1-PTGS2 interaction				[3]
Studied Cell Lines	Human mammary and oral epithelial cell line
Ensembl ID	ENSG00000120738
Description	Early growth response 1 (EGR1) is reported to repress the transcription of COX2 gene, which leads to a decreased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2. As a result, the interaction between EGR1 and COX2 can repress the drug-metabolizing process of Prostaglandin G/H synthase 2.
ETS translocation 4 (ETV4)		Health		Activation
Uniprot ID	ETV4_HUMAN
Interaction Name	ETV4-PTGS2 interaction				[4]
Studied Cell Lines	Mouse mammary epithelial cell line
Ensembl ID	ENSG00000175832
Description	ETS translocation 4 (ETV4) is reported to activate the transcription of COX2 gene, which leads to an increased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2. As a result, the interaction between ETV4 and COX2 can activate the drug-metabolizing process of Prostaglandin G/H synthase 2.
His-acetyltransferase p300 (EP300)		Health		Activation
Uniprot ID	EP300_HUMAN
Interaction Name	EP300-PTGS2 interaction				[5]
Studied Cell Lines	Human foreskin fibroblasts
Description	His-acetyltransferase p300 (EP300) is reported to activate the transcription of COX2 gene, which leads to an increased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2. As a result, the interaction between EP300 and COX2 can activate the drug-metabolizing process of Prostaglandin G/H synthase 2.
Histone deacetylase 1 (HDAC1)		Health		Activation
Uniprot ID	HDAC1_HUMAN
Interaction Name	HDAC1-PTGS2 interaction				[6]
Studied Cell Lines	BEAS-2B cell line
Description	Histone deacetylase 1 (HDAC1) is reported to deacetylate the COX2 gene and thereby represses the transcriptional activity of the drug-metabolizing enzyme Prostaglandin G/H synthase 2. As a result, the interaction between HDAC1 and COX2 can inhibit the drug-metabolizing process of Prostaglandin G/H synthase 2.
Nuclear factor kappa-B p105 (NFKB1)		Health		Activation
Uniprot ID	NFKB1_HUMAN
Interaction Name	NFKB1-PTGS2 interaction				[11], [12], [13]
Studied Cell Lines	Human bronchial epithelial primary cell line
Ensembl ID	ENSG00000109320
Description	Nuclear factor kappa-B p105 (NFKB1) is reported to activate the transcription of COX2 gene, which leads to an increased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2. As a result, the interaction between NFKB1 and COX2 can activate the drug-metabolizing process of Prostaglandin G/H synthase 2.
Proto-oncogene c-Fos (FOS)		Health		Activation
Uniprot ID	FOS_HUMAN
Interaction Name	FOS-PTGS2 interaction				[14]
Studied Cell Lines	Human chondrocytes
Ensembl ID	ENSG00000170345
Description	Proto-oncogene c-Fos (FOS) is reported to activate the transcription of COX2 gene, which leads to an increased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2. As a result, the interaction between FOS and COX2 can activate the drug-metabolizing process of Prostaglandin G/H synthase 2.
SET-binding protein (SETBP1)		Health		Repression
Uniprot ID	SETBP_HUMAN
Interaction Name	SETBP1-PTGS2 interaction				[15]
Studied Cell Lines	Airway structural cell line
Ensembl ID	ENSG00000152217
Description	SET-binding protein (SETBP1) is reported to repress the transcription of COX2 gene, which leads to a decreased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2. As a result, the interaction between SETBP1 and COX2 can repress the drug-metabolizing process of Prostaglandin G/H synthase 2.
TF factor jun-B (JUNB)		Health		Activation
Uniprot ID	JUNB_HUMAN
Interaction Name	JUNB-PTGS2 interaction				[14]
Studied Cell Lines	Human chondrocytes
Ensembl ID	ENSG00000171223
Description	TF factor jun-B (JUNB) is reported to activate the transcription of COX2 gene, which leads to an increased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2. As a result, the interaction between JUNB and COX2 can activate the drug-metabolizing process of Prostaglandin G/H synthase 2.
TF factor jun-D (JUND)		Health		Activation
Uniprot ID	JUND_HUMAN
Interaction Name	JUND-PTGS2 interaction				[14]
Studied Cell Lines	Human chondrocytes
Ensembl ID	ENSG00000130522
Description	TF factor jun-D (JUND) is reported to activate the transcription of COX2 gene, which leads to an increased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2. As a result, the interaction between JUND and COX2 can activate the drug-metabolizing process of Prostaglandin G/H synthase 2.
Transcription factor p65 (RELA)		Health		Activation
Uniprot ID	TF65_HUMAN
Interaction Name	RELA-PTGS2 interaction				[11], [12], [13]
Studied Cell Lines	Human bronchial epithelial primary cell line
Ensembl ID	ENSG00000173039
Description	Transcription factor p65 (RELA) is reported to activate the transcription of COX2 gene, which leads to an increased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2. As a result, the interaction between RELA and COX2 can activate the drug-metabolizing process of Prostaglandin G/H synthase 2.
Non-coding RNA regulation
hsa-miR-146a-5p		Health		Suppression
miRBase ID	MIMAT0000449
Interaction Name	hsa-miR-146a-5p--PTGS2 regulation				[8]
Studied Cell Lines	GES-1 and HEK293 cell lines
Description	hsa-miR-146a-5p is reported to suppress PTGS2 mRNA translation by binding to the 3' untranslated region (3'UTR) of PTGS2 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2.
hsa-miR-199a-5p		Health		Suppression
miRBase ID	MIMAT0000231
Interaction Name	hsa-miR-199a-5p--PTGS2 regulation				[9]
Studied Cell Lines	BEAS-2B cell line
Description	hsa-miR-199a-5p is reported to suppress PTGS2 mRNA translation by binding to the 3' untranslated region (3'UTR) of PTGS2 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2.
hsa-miR-558		Health		Suppression
miRBase ID	MIMAT0003222
Interaction Name	hsa-miR-558--PTGS2 regulation				[10]
Studied Cell Lines	SW1353 cell line
Description	hsa-miR-558 is reported to suppress PTGS2 mRNA translation by binding to the 3' untranslated region (3'UTR) of PTGS2 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2.
Histone modification
Histone methyltransferases (HMTs)		Health		Repression
Uniprot ID	EHMT1_HUMAN
Interaction Name	HMTs-COX2 interaction				[7]
Studied Cell Lines	Mouse embryonic fibroblast cells
Description	The Histone 3 lysine 9 trimethylation of COX2 gene is reported to repress the transcriptional activity of the drug-metabolizing enzyme Prostaglandin G/H synthase 2. As a result, the interaction between Histone methyltransferases (HMTs) and COX2 can inhibit the drug-metabolizing process of Prostaglandin G/H synthase 2.
ICD Disease Classification 02 Neoplasms
ICD-11: 2A00 Brain cancer		Click to Show/Hide the Full List of HOSPPI: 6 HOSPPI
Transcription-factor regulation
Homeobox protein CDX-2 (CDX2)		Glioblastoma		Repression
Uniprot ID	CDX2_HUMAN
Interaction Name	CDX2-PTGS2 interaction				[16]
Studied Cell Lines	U87 cell line
Ensembl ID	ENSG00000165556
Description	Homeobox protein CDX-2 (CDX2) is reported to repress the transcription of COX2 gene, which leads to a decreased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2. As a result, the interaction between CDX2 and COX2 can repress the drug-metabolizing process of Prostaglandin G/H synthase 2.
STAT 3 (STAT3)		Glioblastoma		Activation
Uniprot ID	STAT3_HUMAN
Interaction Name	STAT3-PTGS2 interaction				[19]
Studied Cell Lines	U87MG and T98G cell lines
Ensembl ID	ENSG00000168610
Description	STAT 3 (STAT3) is reported to activate the transcription of COX2 gene, which leads to an increased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2. As a result, the interaction between STAT3 and COX2 can activate the drug-metabolizing process of Prostaglandin G/H synthase 2.
Upstream stimulatory 1 (USF1)		Medulloblastoma		Repression
Uniprot ID	USF1_HUMAN
Interaction Name	USF1-PTGS2 interaction				[20]
Studied Cell Lines	TE671 cell line
Ensembl ID	ENSG00000158773
Description	Upstream stimulatory 1 (USF1) is reported to repress the transcription of COX2 gene, which leads to a decreased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2. As a result, the interaction between USF1 and COX2 can repress the drug-metabolizing process of Prostaglandin G/H synthase 2.
Non-coding RNA regulation
hsa-miR-137		Glioblastoma		Suppression
miRBase ID	MI0000454
Interaction Name	hsa-miR-137--PTGS2 regulation				[17]
Studied Cell Lines	LN229 cell line
Description	hsa-miR-137 is reported to suppress PTGS2 mRNA translation by binding to the 3' untranslated region (3'UTR) of PTGS2 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2.
hsa-miR-26b-5p		Glioblastoma		Suppression
miRBase ID	MIMAT0000083
Interaction Name	hsa-miR-26b-5p--PTGS2 regulation				[18]
Studied Cell Lines	U373 cell line
Description	hsa-miR-26b-5p is reported to suppress PTGS2 mRNA translation by binding to the 3' untranslated region (3'UTR) of PTGS2 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2.
DNA methylation
DNA methyltransferase (DNMT)		Multilayered rosettes embryonal tumour		Significant hypermethylation
Interaction Name	DNMT-COX-2 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypermethylation p-value: 1.36E-20; delta-beta: 8.00E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the COX-2 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2. As a result, the interaction between DNMT and COX-2 can significantly affect the drug-metabolizing process of Prostaglandin G/H synthase 2.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2B30 Lymphoma		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Lymphoma		Significant hypermethylation
Interaction Name	DNMT-COX-2 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypermethylation p-value: 1.66E-17; delta-beta: 5.52E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the COX-2 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2. As a result, the interaction between DNMT and COX-2 can significantly affect the drug-metabolizing process of Prostaglandin G/H synthase 2.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2B90 Colorectal cancer		Click to Show/Hide the Full List of HOSPPI: 5 HOSPPI
Transcription-factor regulation
Adenomatous polyposis coli (APC)		Colorectal cancer		Repression
Uniprot ID	APC_HUMAN
Interaction Name	APC-PTGS2 interaction				[21], [22]
Studied Cell Lines	HT-29 cell line
Description	Adenomatous polyposis coli (APC) is reported to repress the transcription of COX2 gene, which leads to a decreased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2. As a result, the interaction between APC and COX2 can repress the drug-metabolizing process of Prostaglandin G/H synthase 2.
Homeobox protein CDX-2 (CDX2)		Colorectal cancer		Repression
Uniprot ID	CDX2_HUMAN
Interaction Name	CDX2-PTGS2 interaction				[16]
Studied Cell Lines	HCT-116 and SNU-C4 cell lines
Ensembl ID	ENSG00000165556
Description	Homeobox protein CDX-2 (CDX2) is reported to repress the transcription of COX2 gene, which leads to a decreased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2. As a result, the interaction between CDX2 and COX2 can repress the drug-metabolizing process of Prostaglandin G/H synthase 2.
PPA receptor alpha (PPARA)		Colorectal cancer		Activation
Uniprot ID	PPARA_HUMAN
Interaction Name	PPARA-PTGS2 interaction				[23]
Studied Cell Lines	HT-29 cell line
Ensembl ID	ENSG00000186951
Description	PPA receptor alpha (PPARA) is reported to activate the transcription of COX2 gene, which leads to an increased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2. As a result, the interaction between PPARA and COX2 can activate the drug-metabolizing process of Prostaglandin G/H synthase 2.
PPA receptor gamma (PPARG)		Colorectal cancer		Activation
Uniprot ID	PPARG_HUMAN
Interaction Name	PPARG-PTGS2 interaction				[23]
Studied Cell Lines	HT-29 cell line
Ensembl ID	ENSG00000132170
Description	PPA receptor gamma (PPARG) is reported to activate the transcription of COX2 gene, which leads to an increased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2. As a result, the interaction between PPARG and COX2 can activate the drug-metabolizing process of Prostaglandin G/H synthase 2.
Transcription factor Sp1 (SP1)		Colorectal cancer		Activation
Uniprot ID	SP1_HUMAN
Interaction Name	SP1-PTGS2 interaction				[24]
Studied Cell Lines	Colon cancer cell line
Ensembl ID	ENSG00000185591
Description	Transcription factor Sp1 (SP1) is reported to activate the transcription of COX2 gene, which leads to an increased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2. As a result, the interaction between SP1 and COX2 can activate the drug-metabolizing process of Prostaglandin G/H synthase 2.
ICD-11: 2C10 Pancreatic adenocarcinoma		Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
Transcription-factor regulation
High mobility group A1 (HMGA1)		Pancreatic adenocarcinoma		Activation
Uniprot ID	HMGA1_HUMAN
Interaction Name	HMGA1-PTGS2 interaction				[25]
Studied Cell Lines	BxPC-3, HPAF-II, MiaPaCa Panc1, PL45 and XPA-3 cell lines
Ensembl ID	ENSG00000137309
Description	High mobility group A1 (HMGA1) is reported to activate the transcription of COX2 gene, which leads to an increased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2. As a result, the interaction between HMGA1 and COX2 can activate the drug-metabolizing process of Prostaglandin G/H synthase 2.
Non-coding RNA regulation
hsa-miR-143-3p		Pancreatic adenocarcinoma		Suppression
miRBase ID	MIMAT0000435
Interaction Name	hsa-miR-143-3p--PTGS2 regulation				[26]
Studied Cell Lines	BxPC-3 cell line
Description	hsa-miR-143-3p is reported to suppress PTGS2 mRNA translation by binding to the 3' untranslated region (3'UTR) of PTGS2 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2.
ICD-11: 2C12 Liver cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Non-coding RNA regulation
hsa-miR-16-5p		Liver cancer		Suppression
miRBase ID	MIMAT0000069
Interaction Name	hsa-miR-16-5p--PTGS2 regulation				[27]
Studied Cell Lines	WRL68, HepG2 and Hep3B cell lines
Description	hsa-miR-16-5p is reported to suppress PTGS2 mRNA translation by binding to the 3' untranslated region (3'UTR) of PTGS2 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2.
ICD-11: 2C25 Lung cancer		Click to Show/Hide the Full List of HOSPPI: 4 HOSPPI
Transcription-factor regulation
Inhibitor of growth 4 (ING4)		Lung cancer		Repression
Uniprot ID	ING4_HUMAN
Interaction Name	ING4-PTGS2 interaction				[29]
Studied Cell Lines	A549 cell line
Description	Inhibitor of growth 4 (ING4) is reported to repress the transcription of COX2 gene, which leads to a decreased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2. As a result, the interaction between ING4 and COX2 can repress the drug-metabolizing process of Prostaglandin G/H synthase 2.
Liver activator protein (LAP)		Lung cancer		Activation
Uniprot ID	CEBPB_HUMAN
Interaction Name	LAP-PTGS2 interaction				[11], [30]
Studied Cell Lines	NCI-H520, NCI-H460, and NCI-H1299 cell lines
Ensembl ID	ENSG00000172216
Description	Liver activator protein (LAP) is reported to activate the transcription of COX2 gene, which leads to an increased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2. As a result, the interaction between LAP and COX2 can activate the drug-metabolizing process of Prostaglandin G/H synthase 2.
STAT 6 (STAT6)		Lung cancer		Activation
Uniprot ID	STAT6_HUMAN
Interaction Name	STAT6-PTGS2 interaction				[31]
Studied Cell Lines	A427 and H2122 cell lines
Ensembl ID	ENSG00000166888
Description	STAT 6 (STAT6) is reported to activate the transcription of COX2 gene, which leads to an increased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2. As a result, the interaction between STAT6 and COX2 can activate the drug-metabolizing process of Prostaglandin G/H synthase 2.
Non-coding RNA regulation
hsa-miR-589-5p		Lung cancer		Suppression
miRBase ID	MIMAT0004799
Interaction Name	hsa-miR-589-5p--PTGS2 regulation				[28]
Studied Cell Lines	A549 cell line
Description	hsa-miR-589-5p is reported to suppress PTGS2 mRNA translation by binding to the 3' untranslated region (3'UTR) of PTGS2 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2.
ICD-11: 2C60 Breast cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Transcription-factor regulation
Progesterone receptor (PGR)		Breast cancer		Repression
Uniprot ID	PRGR_HUMAN
Interaction Name	PGR-PTGS2 interaction				[32]
Studied Cell Lines	T47D and MCF-7 cell lines
Ensembl ID	ENSG00000082175
Description	Progesterone receptor (PGR) is reported to repress the transcription of COX2 gene, which leads to a decreased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2. As a result, the interaction between PGR and COX2 can repress the drug-metabolizing process of Prostaglandin G/H synthase 2.
ICD-11: 2C73 Ovarian cancer		Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
Transcription-factor regulation
Homeobox protein CDX-1 (CDX1)		Ovarian cancer		Activation
Uniprot ID	CDX1_HUMAN
Interaction Name	CDX1-PTGS2 interaction				[33]
Studied Cell Lines	SKOV3 and A2780 cell lines
Ensembl ID	ENSG00000113722
Description	Homeobox protein CDX-1 (CDX1) is reported to activate the transcription of COX2 gene, which leads to an increased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2. As a result, the interaction between CDX1 and COX2 can activate the drug-metabolizing process of Prostaglandin G/H synthase 2.
Nuclear receptor family 0 B2 (NR0B2)		Ovarian cancer		Activation
Uniprot ID	NR0B2_HUMAN
Interaction Name	NR0B2-PTGS2 interaction				[33]
Studied Cell Lines	SKOV3 and A2780 cell lines
Ensembl ID	ENSG00000131910
Description	Nuclear receptor family 0 B2 (NR0B2) is reported to activate the transcription of COX2 gene, which leads to an increased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2. As a result, the interaction between NR0B2 and COX2 can activate the drug-metabolizing process of Prostaglandin G/H synthase 2.
ICD-11: 2C77 Cervical cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Transcription-factor regulation
PPA receptor gamma (PPARG)		Cervical cancer		Repression
Uniprot ID	PPARG_HUMAN
Interaction Name	PPARG-PTGS2 interaction				[34], [35]
Studied Cell Lines	CaSki cell line
Ensembl ID	ENSG00000132170
Description	PPA receptor gamma (PPARG) is reported to repress the transcription of COX2 gene, which leads to a decreased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2. As a result, the interaction between PPARG and COX2 can repress the drug-metabolizing process of Prostaglandin G/H synthase 2.
ICD-11: 2C82 Prostate cancer		Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
Transcription-factor regulation
Androgen receptor (AR)		Prostate cancer		Repression
Uniprot ID	ANDR_HUMAN
Interaction Name	AR-PTGS2 interaction				[36]
Studied Cell Lines	LNCaP and PC-3 cell lines
Ensembl ID	ENSG00000169083
Description	Androgen receptor (AR) is reported to repress the transcription of COX2 gene, which leads to a decreased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2. As a result, the interaction between AR and COX2 can repress the drug-metabolizing process of Prostaglandin G/H synthase 2.
Non-coding RNA regulation
hsa-miR-26a-5p		Prostate cancer		Suppression
miRBase ID	MIMAT0000082
Interaction Name	hsa-miR-26a-5p--PTGS2 regulation				[37]
Studied Cell Lines	LNCaP cell line
Description	hsa-miR-26a-5p is reported to suppress PTGS2 mRNA translation by binding to the 3' untranslated region (3'UTR) of PTGS2 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2.
ICD-11: 2E60 Esophageal squamous cell carcinoma		Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
Non-coding RNA regulation
hsa-miR-101-3p		Esophageal squamous cell carcinoma		Suppression
miRBase ID	MIMAT0000099
Interaction Name	hsa-miR-101-3p--PTGS2 regulation				[38]
Studied Cell Lines	EC9706 cell line
Description	hsa-miR-101-3p is reported to suppress PTGS2 mRNA translation by binding to the 3' untranslated region (3'UTR) of PTGS2 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2.
hsa-miR-144-3p		Esophageal squamous cell carcinoma		Suppression
miRBase ID	MIMAT0000436
Interaction Name	hsa-miR-144-3p--PTGS2 regulation				[39]
Studied Cell Lines	EC9706 cell line
Description	hsa-miR-144-3p is reported to suppress PTGS2 mRNA translation by binding to the 3' untranslated region (3'UTR) of PTGS2 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2.
ICD-11: 2E64 Skin cancer		Click to Show/Hide the Full List of HOSPPI: 3 HOSPPI
Transcription-factor regulation
Histone deacetylase 4 (HDAC4)		Epidermoid carcinoma		Activation
Uniprot ID	HDAC4_HUMAN
Interaction Name	HDAC4-PTGS2 interaction				[40]
Studied Cell Lines	A431 cell line
Description	Histone deacetylase 4 (HDAC4) is reported to deacetylate the COX2 gene and thereby represses the transcriptional activity of the drug-metabolizing enzyme Prostaglandin G/H synthase 2. As a result, the interaction between HDAC4 and COX2 can inhibit the drug-metabolizing process of Prostaglandin G/H synthase 2.
Liver activator protein (LAP)		Epidermoid carcinoma		Repression
Uniprot ID	CEBPB_HUMAN
Interaction Name	LAP-PTGS2 interaction				[40]
Studied Cell Lines	A431 cell line
Ensembl ID	ENSG00000172216
Description	Liver activator protein (LAP) is reported to repress the transcription of COX2 gene, which leads to a decreased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2. As a result, the interaction between LAP and COX2 can repress the drug-metabolizing process of Prostaglandin G/H synthase 2.
Transcription factor AP-1 (JUN)		Epidermoid carcinoma		Activation
Uniprot ID	JUN_HUMAN
Interaction Name	JUN-PTGS2 interaction				[11], [14], [41]
Studied Cell Lines	A431 cell line
Ensembl ID	ENSG00000177606
Description	Transcription factor AP-1 (JUN) is reported to activate the transcription of COX2 gene, which leads to an increased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2. As a result, the interaction between JUN and COX2 can activate the drug-metabolizing process of Prostaglandin G/H synthase 2.
ICD Disease Classification 11 Circulatory system diseases
ICD-11: BA6Z Myocardial ischemia		Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
Transcription-factor regulation
STAT 1-alpha/beta (STAT1)		Myocardial ischemia/reperfusion injury		Activation
Uniprot ID	STAT1_HUMAN
Interaction Name	STAT1-PTGS2 interaction				[42]
Studied Cell Lines	Myocardial ischemia/reperfusion injury cell line
Ensembl ID	ENSG00000115415
Description	STAT 1-alpha/beta (STAT1) is reported to activate the transcription of COX2 gene, which leads to an increased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2. As a result, the interaction between STAT1 and COX2 can activate the drug-metabolizing process of Prostaglandin G/H synthase 2.
STAT 2 (STAT2)		Myocardial ischemia/reperfusion injury		Activation
Uniprot ID	STAT2_HUMAN
Interaction Name	STAT2-PTGS2 interaction				[42]
Studied Cell Lines	Myocardial ischemia/reperfusion injury cell line
Ensembl ID	ENSG00000170581
Description	STAT 2 (STAT2) is reported to activate the transcription of COX2 gene, which leads to an increased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2. As a result, the interaction between STAT2 and COX2 can activate the drug-metabolizing process of Prostaglandin G/H synthase 2.
ICD Disease Classification 12 Respiratory system diseases
ICD-11: CA23 Asthma		Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
Transcription-factor regulation
Nuclear factor kappa-B p105 (NFKB1)		Asthma		Repression
Uniprot ID	NFKB1_HUMAN
Interaction Name	NFKB1-PTGS2 interaction				[43], [3]
Studied Cell Lines	Nasal polyps from aspirin-intolerant asthma/rhinitis patients
Ensembl ID	ENSG00000109320
Description	Nuclear factor kappa-B p105 (NFKB1) is reported to repress the transcription of COX2 gene, which leads to a decreased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2. As a result, the interaction between NFKB1 and COX2 can repress the drug-metabolizing process of Prostaglandin G/H synthase 2.
Transcription factor p65 (RELA)		Asthma		Repression
Uniprot ID	TF65_HUMAN
Interaction Name	RELA-PTGS2 interaction				[43], [3]
Studied Cell Lines	Nasal polyps from aspirin-intolerant asthma/rhinitis patients
Ensembl ID	ENSG00000173039
Description	Transcription factor p65 (RELA) is reported to repress the transcription of COX2 gene, which leads to a decreased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2. As a result, the interaction between RELA and COX2 can repress the drug-metabolizing process of Prostaglandin G/H synthase 2.
ICD Disease Classification 15 Musculoskeletal system diseases
ICD-11: FA00 Osteoarthritis		Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
Transcription-factor regulation
Protein Dr1 (DR1)		Osteoarthritis		Activation
Uniprot ID	NC2B_HUMAN
Interaction Name	DR1-PTGS2 interaction				[45]
Studied Cell Lines	Synovial lining cell linr
Description	Protein Dr1 (DR1) is reported to activate the transcription of COX2 gene, which leads to an increased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2. As a result, the interaction between DR1 and COX2 can activate the drug-metabolizing process of Prostaglandin G/H synthase 2.
Non-coding RNA regulation
hsa-miR-199a-3p		Osteoarthritis		Suppression
miRBase ID	MIMAT0000232
Interaction Name	hsa-miR-199a-3p--PTGS2 regulation				[44]
Studied Cell Lines	Osteoarthritis chondrocytes
Description	hsa-miR-199a-3p is reported to suppress PTGS2 mRNA translation by binding to the 3' untranslated region (3'UTR) of PTGS2 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Prostaglandin G/H synthase 2.

References
1	Cross talk between PKC and CREB in the induction of COX-2 by PGF2alpha in human amnion fibroblasts. Endocrinology. 2012 Oct;153(10):4938-45.
2	Human cyclooxygenase-2 is a sequence homodimer that functions as a conformational heterodimer. J Biol Chem. 2011 May 27;286(21):19035-46.
3	Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res. 2004 Sep-Oct;24(5A):2783-840.
4	PEA3 is up-regulated in response to Wnt1 and activates the expression of cyclooxygenase-2. J Biol Chem. 2001 Jun 8;276(23):20108-15.
5	Up-regulation of p300 binding and p50 acetylation in tumor necrosis factor-alpha-induced cyclooxygenase-2 promoter activation. J Biol Chem. 2003 Feb 14;278(7):4770-7.
6	COX-2 expression induced by diesel particles involves chromatin modification and degradation of HDAC1. Am J Respir Cell Mol Biol. 2007 Aug;37(2):232-9.
7	Methionine adenosyltransferase II-dependent histone H3K9 methylation at the COX-2 gene locus. J Biol Chem. 2013 May 10;288(19):13592-601.
8	MicroRNA-146a negatively regulates PTGS2 expression induced by Helicobacter pylori in human gastric epithelial cells. J Gastroenterol. 2013 Jan;48(1):86-92.
9	Chronic arsenic exposure and angiogenesis in human bronchial epithelial cells via the ROS/miR-199a-5p/HIF-1alpha/COX-2 pathway. Environ Health Perspect. 2014 Mar;122(3):255-61.
10	MicroRNA-558 regulates the expression of cyclooxygenase-2 and IL-1beta-induced catabolic effects in human articular chondrocytes. Osteoarthritis Cartilage. 2013 Jul;21(7):981-9.
11	Lysophosphatidic acid-induced transactivation of epidermal growth factor receptor regulates cyclo-oxygenase-2 expression and prostaglandin E(2) release via C/EBPbeta in human bronchial epithelial cells. Biochem J. 2008 May 15;412(1):153-62.
12	Toll-like receptor 9 agonists up-regulates the expression of cyclooxygenase-2 via activation of NF-kappaB in prostate cancer cells. Mol Biol Rep. 2010 Apr;37(4):1849-55.
13	Minimizing the cancer-promotional activity of cox-2 as a central strategy in cancer prevention. Med Hypotheses. 2012 Jan;78(1):45-57.
14	Transcriptional induction of cyclooxygenase-2 gene by okadaic acid inhibition of phosphatase activity in human chondrocytes: co-stimulation of AP-1 and CRE nuclear binding proteins. J Cell Biochem. 1998 Jun 15;69(4):392-413.
15	Staphylococcus aureus enterotoxin B regulates prostaglandin E2 synthesis, growth, and migration in nasal tissue fibroblasts. J Infect Dis. 2008 Apr 1;197(7):1036-43.
16	Homeodomain protein CDX2 regulates COX-2 expression in colorectal cancer. Biochem Biophys Res Commun. 2004 Feb 27;315(1):93-9.
17	miR-137 is frequently down-regulated in glioblastoma and is a negative regulator of Cox-2. Eur J Cancer. 2012 Nov;48(16):3104-11.
18	miR-26b Mimic Inhibits Glioma Proliferation In Vitro and In Vivo Suppressing COX-2 Expression. Oncol Res. 2019 Feb 5;27(2):147-155.
19	Cyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axes. Mol Cancer Res. 2010 Feb;8(2):232-45.
20	Enhancement of prostaglandin D(2) production through cyclooxygenase-2 and lipocalin-type prostaglandin D synthase by upstream stimulatory factor 1 in human brain-derived TE671 cells under serum starvation. Gene. 2008 Dec 15;426(1-2):72-80.
21	Lack of cyclooxygenase-2 activity in HT-29 human colorectal carcinoma cells. Exp Cell Res. 2000 May 1;256(2):563-70.
22	Regulation of cyclooxygenase-2 expression by the Wnt and ras pathways. Cancer Res. 2003 Feb 1;63(3):728-34.
23	Effect of PPAR activators on cytokine-stimulated cyclooxygenase-2 expression in human colorectal carcinoma cells. Exp Cell Res. 2001 Jul 1;267(1):73-80.
24	PTGS2 (COX-2) -765G > C promoter variant reduces risk of colorectal adenoma among nonusers of nonsteroidal anti-inflammatory drugs. Cancer Epidemiol Biomarkers Prev. 2005 Mar;14(3):616-9.
25	The HMGA1-COX-2 axis: a key molecular pathway and potential target in pancreatic adenocarcinoma. Pancreatology. 2012 Jul-Aug;12(4):372-9.
26	miR-143 decreases COX-2 mRNA stability and expression in pancreatic cancer cells. Biochem Biophys Res Commun. 2013 Sep 13;439(1):6-11.
27	Cyclooxygenase-2 is a target of microRNA-16 in human hepatoma cells. PLoS One. 2012;7(11):e50935.
28	Promoter RNA links transcriptional regulation of inflammatory pathway genes. Nucleic Acids Res. 2013 Dec;41(22):10086-109.
29	ING4 induces cell growth inhibition in human lung adenocarcinoma A549 cells by means of Wnt-1/beta-catenin signaling pathway. Anat Rec (Hoboken). 2008 May;291(5):593-600.
30	PC-SPES down-regulates COX-2 via inhibition of NF-kappaB and C/EBPbeta in non-small cell lung cancer cells. Int J Oncol. 2006 Aug;29(2):453-61.
31	Unphosphorylated STAT6 contributes to constitutive cyclooxygenase-2 expression in human non-small cell lung cancer. Oncogene. 2007 Jun 21;26(29):4253-60.
32	Progesterone receptor inhibits aromatase and inflammatory response pathways in breast cancer cells via ligand-dependent and ligand-independent mechanisms. Mol Endocrinol. 2008 Aug;22(8):1812-24.
33	Hypoxia induces expression of COX-2 through the homeodomain transcription factor CDX1 and orphan nuclear receptor SHP in human endometrial cells. Mol Hum Reprod. 2011 Nov;17(11):710-9.
34	Control of COX-2 gene expression through peroxisome proliferator-activated receptor gamma in human cervical cancer cells. Clin Cancer Res. 2003 Oct 1;9(12):4627-35.
35	NF-kappaB/PPAR gamma and/or AP-1/PPAR gamma 'on/off' switches and induction of CBP in colon adenocarcinomas: correlation with COX-2 expression. Int J Colorectal Dis. 2007 Jan;22(1):57-68.
36	A new prostate cancer therapeutic approach: combination of androgen ablation with COX-2 inhibitor. Int J Cancer. 2008 Jul 1;123(1):195-201.
37	Downregulated microRNA-26a modulates prostate cancer cell proliferation and apoptosis by targeting COX-2. Oncol Lett. 2016 Nov;12(5):3397-3402.
38	Cyclooxygenase-2, a Potential Therapeutic Target, Is Regulated by miR-101 in Esophageal Squamous Cell Carcinoma. PLoS One. 2015 Nov 10;10(11):e0140642.
39	MiR-26a and miR-144 inhibit proliferation and metastasis of esophageal squamous cell cancer by inhibiting cyclooxygenase-2. Oncotarget. 2016 Mar 22;7(12):15173-86.
40	Sumoylation of LAP1 is involved in the HDAC4-mediated repression of COX-2 transcription. Nucleic Acids Res. 2008 Nov;36(19):6066-79.
41	Activating protein 1-mediated cyclooxygenase-2 expression Is independent of N-terminal phosphorylation of c-Jun. Mol Pharmacol. 2005 Jun;67(6):2057-69.
42	Role of the JAK-STAT pathway in protection against myocardial ischemia/reperfusion injury. Trends Cardiovasc Med. 2003 Feb;13(2):72-9.
43	Nuclear factor-kappaB activity is down-regulated in nasal polyps from aspirin-sensitive asthmatics. Allergy. 2003 Feb;58(2):122-6.
44	MicroRNA-199a* regulates the expression of cyclooxygenase-2 in human chondrocytes. Ann Rheum Dis. 2012 Jun;71(6):1073-80.
45	Nimesulide, a preferential cyclooxygenase 2 inhibitor, suppresses peroxisome proliferator-activated receptor induction of cyclooxygenase 2 gene expression in human synovial fibroblasts: evidence for receptor antagonism. Arthritis Rheum. 2002 Feb;46(2):494-506.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.