Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0116) | |||||
|---|---|---|---|---|---|
| DME Name | Alpha-methylacyl-CoA racemase (AMACR), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 5.1.99.4 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Anaplastic pilocytic astrocytoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-AMACR interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 3.73E-09; delta-beta: -2.10E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the AMACR gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Alpha-methylacyl-CoA racemase. As a result, the interaction between DNMT and AMACR can moderatly affect the drug-metabolizing process of Alpha-methylacyl-CoA racemase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-AMACR interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 9.03E-16; delta-beta: -6.22E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the AMACR gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Alpha-methylacyl-CoA racemase. As a result, the interaction between DNMT and AMACR can significantly affect the drug-metabolizing process of Alpha-methylacyl-CoA racemase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| ICD-11: 2C82 Prostate cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| Non-coding RNA regulation | |||||
| hsa-miR-26a-5p | Prostate cancer | Suppression | |||
| miRBase ID | |||||
| Interaction Name | hsa-miR-26a-5p--AMACR regulation | [1] | |||
| Studied Cell Lines | DU145, PC3 and LNCaP cell lines | ||||
| Description | hsa-miR-26a-5p is reported to suppress AMACR mRNA translation by binding to the 3' untranslated region (3'UTR) of AMACR mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Alpha-methylacyl-CoA racemase. | ||||
| References | |||||
|---|---|---|---|---|---|
| 1 | Elevated expression of prostate cancer-associated genes is linked to down-regulation of microRNAs. BMC Cancer. 2014 Feb 11;14:82. | ||||
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