| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification 02 Neoplasms |
| ICD-11: 2B71 Gastric cancer |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Histone modification |
| Histone deacetylases (HDACs) |
Gastric cancer |
Repression |
| Uniprot ID |
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| Interaction Name |
HDACs-AKR1C3 interaction |
[1] |
| Studied Cell Lines |
HGC-27 cell line |
| Description |
Histone deacetylases (HDACs) are reported to deacetylate the AKR1C3 gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme Aldo-keto reductase 1C3. As a result, the interaction between HDACs and AKR1C3 can inhibit the drug-metabolizing process of Aldo-keto reductase 1C3. |
| ICD-11: 2C82 Prostate cancer |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
|
| Transcription-factor regulation |
| Androgen receptor (AR) |
Prostate cancer |
Repression |
| Uniprot ID |
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| Interaction Name |
AR-AKR1C3 interaction |
[2] |
| Studied Cell Lines |
LNCaP cell line |
| Ensembl ID |
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| Description |
Androgen receptor (AR) is reported to repress the transcription of AKR1C3 gene, which leads to a decreased expression of the drug-metabolizing enzyme Aldo-keto reductase 1C3. As a result, the interaction between AR and AKR1C3 can repress the drug-metabolizing process of Aldo-keto reductase 1C3. |
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