Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0122) | |||||
|---|---|---|---|---|---|
| DME Name | Nitric oxide synthase brain (NOS1), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 1.14.13.39 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification Healthy | |||||
| ICD-11: Healthy | Click to Show/Hide the Full List of HOSPPI: 3 HOSPPI | ||||
| Transcription-factor regulation | |||||
| Nuclear factor kappa-B p105 (NFKB1) | Health | Activation | |||
| Uniprot ID | |||||
| Interaction Name | NFKB1-NOS1 interaction | [2] | |||
| Studied Cell Lines | Human umbilical endothelial cell line | ||||
| Ensembl ID | |||||
| Description | Nuclear factor kappa-B p105 (NFKB1) is reported to activate the transcription of NOS1 gene, which leads to an increased expression of the drug-metabolizing enzyme Nitric oxide synthase brain. As a result, the interaction between NFKB1 and NOS1 can activate the drug-metabolizing process of Nitric oxide synthase brain. | ||||
| Transcription factor p65 (RELA) | Health | Activation | |||
| Uniprot ID | |||||
| Interaction Name | RELA-NOS1 interaction | [2] | |||
| Studied Cell Lines | Human umbilical endothelial cell line | ||||
| Ensembl ID | |||||
| Description | Transcription factor p65 (RELA) is reported to activate the transcription of NOS1 gene, which leads to an increased expression of the drug-metabolizing enzyme Nitric oxide synthase brain. As a result, the interaction between RELA and NOS1 can activate the drug-metabolizing process of Nitric oxide synthase brain. | ||||
| Non-coding RNA regulation | |||||
| hsa-miR-146a-5p | Health | Suppression | |||
| miRBase ID | |||||
| Interaction Name | hsa-miR-146a-5p--NOS1 regulation | [1] | |||
| Studied Cell Lines | HTR-8/SVneo cell line | ||||
| Description | hsa-miR-146a-5p is reported to suppress NOS1 mRNA translation by binding to the 3' untranslated region (3'UTR) of NOS1 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Nitric oxide synthase brain. | ||||
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Oligodendroglial tumour | Moderate hypermethylation | |||
| Interaction Name | DNMT-NOS1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 3.34E-09; delta-beta: 2.36E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the NOS1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Nitric oxide synthase brain. As a result, the interaction between DNMT and NOS1 can moderatly affect the drug-metabolizing process of Nitric oxide synthase brain. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Oligodendroglioma | Significant hypermethylation | |||
| Interaction Name | DNMT-NOS1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.22E-65; delta-beta: 5.28E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the NOS1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Nitric oxide synthase brain. As a result, the interaction between DNMT and NOS1 can significantly affect the drug-metabolizing process of Nitric oxide synthase brain. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2A11 Brain neuroblastoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| Transcription-factor regulation | |||||
| Nuclear receptor family 0 B1 (NR0B1) | Neuroblastoma | Activation | |||
| Uniprot ID | |||||
| Interaction Name | NR0B1-NOS1 interaction | [3] | |||
| Studied Cell Lines | TGW-nu-I cell line | ||||
| Ensembl ID | |||||
| Description | Nuclear receptor family 0 B1 (NR0B1) is reported to activate the transcription of NOS1 gene, which leads to an increased expression of the drug-metabolizing enzyme Nitric oxide synthase brain. As a result, the interaction between NR0B1 and NOS1 can activate the drug-metabolizing process of Nitric oxide synthase brain. | ||||
| ICD-11: 2B30 Lymphoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lymphoma | Significant hypermethylation | |||
| Interaction Name | DNMT-NOS1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 9.11E-33; delta-beta: 6.71E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the NOS1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Nitric oxide synthase brain. As a result, the interaction between DNMT and NOS1 can significantly affect the drug-metabolizing process of Nitric oxide synthase brain. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B71 Gastric cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Gastric cancer | Moderate hypermethylation | |||
| Interaction Name | DNMT-NOS1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 1.55E-29; delta-beta: 2.20E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the NOS1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Nitric oxide synthase brain. As a result, the interaction between DNMT and NOS1 can moderatly affect the drug-metabolizing process of Nitric oxide synthase brain. | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Significant hypermethylation p-value: 8.17E-16; delta-beta: 3.27E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the NOS1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Nitric oxide synthase brain. As a result, the interaction between DNMT and NOS1 can significantly affect the drug-metabolizing process of Nitric oxide synthase brain. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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