Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0125)
DME Name DOPA decarboxylase (DDC), Homo sapiens DME Info
UniProt ID
DDC_HUMAN
EC Number    EC: 4.1.1.28     (Click to Show/Hide the Complete EC Tree)
Lyases
Carbon-carbon lyase
Carboxy-lyase
EC: 4.1.1.28
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2B30 Lymphoma Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Lymphoma Moderate hypomethylation
Interaction Name DNMT-DDC interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Moderate hypomethylation
p-value: 1.83E-08; delta-beta: -2.97E-01
Description DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the DDC gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme DOPA decarboxylase. As a result, the interaction between DNMT and DDC can moderatly affect the drug-metabolizing process of DOPA decarboxylase.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples
Download DME methylation data of patients in the disease section of the tissue
Download DME methylation data in the tissue of healthy individual
               ICD-11: 2C82 Prostate cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Non-coding RNA regulation
                            hsa-miR-145-5p Prostate cancer Suppression
miRBase ID
MIMAT0000437
Interaction Name hsa-miR-145-5p--DDC regulation [1]
Studied Cell Lines LNCaP cell line
Description hsa-miR-145-5p is reported to suppress DDC mRNA translation by binding to the 3' untranslated region (3'UTR) of DDC mRNA, which leads to a decreased expression of the drug-metabolizing enzyme DOPA decarboxylase.
References
1 Human L-DOPA decarboxylase mRNA is a target of miR-145: A prediction to validation workflow. Gene. 2015 Jan 10;554(2):174-80.

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