| General Information of Drug-Metabolizing Enzyme (DME ID: DME0126) |
| DME Name |
L-glutamine amidohydrolase (GLS), Homo sapiens
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DME Info
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| UniProt ID |
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| EC Number |
EC: 3.5.1.2 (Click to Show/Hide the Complete EC Tree)
Hydrolases
Carbon-nitrogen hydrolase
Linear amide hydrolase
EC: 3.5.1.2
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| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Interactome |
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| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification Healthy |
| ICD-11: Healthy |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Non-coding RNA regulation |
| hsa-miR-23a-3p |
Health |
Suppression |
| miRBase ID |
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| Interaction Name |
hsa-miR-23a-3p--GLS regulation |
[1] |
| Studied Cell Lines |
ARPE-19 cell line |
| Description |
hsa-miR-23a-3p is reported to suppress GLS mRNA translation by binding to the 3' untranslated region (3'UTR) of GLS mRNA, which leads to a decreased expression of the drug-metabolizing enzyme L-glutamine amidohydrolase. |
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| References |
| 1 |
Inhibition of the oxidative stress-induced miR-23a protects the human retinal pigment epithelium (RPE) cells from apoptosis through the upregulation of glutaminase and glutamine uptake. Mol Biol Rep. 2016 Oct;43(10):1079-87.
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