General Information of Drug-Metabolizing Enzyme (DME ID: DME0127)
DME Name Alcohol dehydrogenase class-I alpha (ADH1A), Homo sapiens DME Info
UniProt ID
ADH1A_HUMAN
EC Number    EC: 1.1.1.1     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.1
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification Healthy
               ICD-11: Healthy Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Transcription-factor regulation
                            GATA-binding factor 2 (GATA2) Health Activation
Uniprot ID
GATA2_HUMAN
Interaction Name GATA2-ADH1A interaction [1]
Studied Cell Lines H4IIE-C3 and CV-1 cell lines
Ensembl ID
ENSG00000179348
Description GATA-binding factor 2 (GATA2) is reported to activate the transcription of ADH1A gene, which leads to an increased expression of the drug-metabolizing enzyme Alcohol dehydrogenase class-I alpha. As a result, the interaction between GATA2 and ADH1A can activate the drug-metabolizing process of Alcohol dehydrogenase class-I alpha.
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2C12 Liver cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Histone modification
                            Histone deacetylase 1 (HDAC1) Liver cancer Repression
Uniprot ID
HDAC1_HUMAN
Interaction Name HDAC1-ADH1A interaction [2]
Studied Cell Lines HepG2 cell line
Description Histone deacetylase 1 (HDAC1) is reported to deacetylate the ADH1A gene and thereby represses the transcriptional activity of the drug-metabolizing enzyme Alcohol dehydrogenase class-I alpha. As a result, the interaction between HDAC1 and ADH1A can inhibit the drug-metabolizing process of Alcohol dehydrogenase class-I alpha.
References
1 GATA-2 and HNF-3beta regulate the human alcohol dehydrogenase 1A (ADH1A) gene. DNA Cell Biol. 2005 Sep;24(9):543-52.
2 mTOR/HDAC1 Crosstalk Mediated Suppression of ADH1A and ALDH2 Links Alcohol Metabolism to Hepatocellular Carcinoma Onset and Progression in silico. Front Oncol. 2019 Oct 4;9:1000.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.