| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification Healthy |
| ICD-11: Healthy |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
|
| Transcription-factor regulation |
| GATA-binding factor 2 (GATA2) |
Health |
Activation |
| Uniprot ID |
|
| Interaction Name |
GATA2-ADH1A interaction |
[1] |
| Studied Cell Lines |
H4IIE-C3 and CV-1 cell lines |
| Ensembl ID |
|
| Description |
GATA-binding factor 2 (GATA2) is reported to activate the transcription of ADH1A gene, which leads to an increased expression of the drug-metabolizing enzyme Alcohol dehydrogenase class-I alpha. As a result, the interaction between GATA2 and ADH1A can activate the drug-metabolizing process of Alcohol dehydrogenase class-I alpha. |
| ICD Disease Classification 02 Neoplasms |
| ICD-11: 2C12 Liver cancer |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
|
| Histone modification |
| Histone deacetylase 1 (HDAC1) |
Liver cancer |
Repression |
| Uniprot ID |
|
| Interaction Name |
HDAC1-ADH1A interaction |
[2] |
| Studied Cell Lines |
HepG2 cell line |
| Description |
Histone deacetylase 1 (HDAC1) is reported to deacetylate the ADH1A gene and thereby represses the transcriptional activity of the drug-metabolizing enzyme Alcohol dehydrogenase class-I alpha. As a result, the interaction between HDAC1 and ADH1A can inhibit the drug-metabolizing process of Alcohol dehydrogenase class-I alpha. |
|
|
|
|
|
|
