| General Information of Drug-Metabolizing Enzyme (DME ID: DME0129) |
| DME Name |
Alcohol dehydrogenase class-I gamma (ADH1C), Homo sapiens
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DME Info
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| UniProt ID |
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| EC Number |
EC: 1.1.1.1 (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH-OH donor oxidoreductase
NAD/NADP oxidoreductase
EC: 1.1.1.1
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| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Interactome |
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| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification 02 Neoplasms |
| ICD-11: 2C12 Liver cancer |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Histone modification |
| Histone deacetylases (HDACs) |
Liver cancer |
Repression |
| Uniprot ID |
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| Interaction Name |
HDACs-ADH1C interaction |
[1] |
| Studied Cell Lines |
HepG2 cell line |
| Description |
Histone deacetylases (HDACs) are reported to deacetylate the ADH1C gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme Alcohol dehydrogenase class-I gamma. As a result, the interaction between HDACs and ADH1C can inhibit the drug-metabolizing process of Alcohol dehydrogenase class-I gamma. |
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| References |
| 1 |
Differential regulation of the alcohol dehydrogenase 1B (ADH1B) and ADH1C genes by DNA methylation and histone deacetylation. Alcohol Clin Exp Res. 2006 Jun;30(6):928-37.
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