Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0131) | |||||
|---|---|---|---|---|---|
| DME Name | Gastric alcohol dehydrogenase (ADH7), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 1.1.1.105 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 3 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Anaplastic pilocytic astrocytoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-ADH7 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.47E-06; delta-beta: -2.05E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the ADH7 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Gastric alcohol dehydrogenase. As a result, the interaction between DNMT and ADH7 can moderatly affect the drug-metabolizing process of Gastric alcohol dehydrogenase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-ADH7 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 2.34E-11; delta-beta: -3.62E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the ADH7 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Gastric alcohol dehydrogenase. As a result, the interaction between DNMT and ADH7 can significantly affect the drug-metabolizing process of Gastric alcohol dehydrogenase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Peripheral neuroectodermal tumour | Significant hypomethylation | |||
| Interaction Name | DNMT-ADH7 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 5.91E-06; delta-beta: -3.74E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the ADH7 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Gastric alcohol dehydrogenase. As a result, the interaction between DNMT and ADH7 can significantly affect the drug-metabolizing process of Gastric alcohol dehydrogenase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B30 Lymphoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lymphoma | Significant hypomethylation | |||
| Interaction Name | DNMT-ADH7 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.18E-08; delta-beta: -3.75E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the ADH7 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Gastric alcohol dehydrogenase. As a result, the interaction between DNMT and ADH7 can significantly affect the drug-metabolizing process of Gastric alcohol dehydrogenase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C25 Lung cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lung cancer | Significant hypomethylation | |||
| Interaction Name | DNMT-ADH7 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.57E-33; delta-beta: -4.98E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the ADH7 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Gastric alcohol dehydrogenase. As a result, the interaction between DNMT and ADH7 can significantly affect the drug-metabolizing process of Gastric alcohol dehydrogenase. | ||||
| The Methylation Level of Disease Section Compare with the Other Disease Section | Significant hypomethylation p-value: 2.43E-24; delta-beta: -4.99E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the ADH7 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Gastric alcohol dehydrogenase. As a result, the interaction between DNMT and ADH7 can significantly affect the drug-metabolizing process of Gastric alcohol dehydrogenase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
DME methylation in tissue other than the diseased tissue of patients
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| ICD-11: 2F9A Endocrine gland cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Craniopharyngioma | Significant hypomethylation | |||
| Interaction Name | DNMT-ADH7 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.10E-21; delta-beta: -7.12E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the ADH7 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Gastric alcohol dehydrogenase. As a result, the interaction between DNMT and ADH7 can significantly affect the drug-metabolizing process of Gastric alcohol dehydrogenase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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