| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification 02 Neoplasms |
| ICD-11: 2C60 Breast cancer |
Click to Show/Hide the Full List of HOSPPI: 3 HOSPPI
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| Transcription-factor regulation |
| Nuclear factor kappa-B p105 (NFKB1) |
Breast cancer |
Activation |
| Uniprot ID |
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| Interaction Name |
NFKB1-UPP1 interaction |
[1] |
| Studied Cell Lines |
EMT6 cell line |
| Ensembl ID |
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| Description |
Nuclear factor kappa-B p105 (NFKB1) is reported to activate the transcription of UPP1 gene, which leads to an increased expression of the drug-metabolizing enzyme Uridine phosphorylase 1. As a result, the interaction between NFKB1 and UPP1 can activate the drug-metabolizing process of Uridine phosphorylase 1. |
| STAT 1-alpha/beta (STAT1) |
Breast cancer |
Activation |
| Uniprot ID |
|
| Interaction Name |
STAT1-UPP1 interaction |
[1] |
| Studied Cell Lines |
EMT6 cell line |
| Ensembl ID |
|
| Description |
STAT 1-alpha/beta (STAT1) is reported to activate the transcription of UPP1 gene, which leads to an increased expression of the drug-metabolizing enzyme Uridine phosphorylase 1. As a result, the interaction between STAT1 and UPP1 can activate the drug-metabolizing process of Uridine phosphorylase 1. |
| Transcription factor p65 (RELA) |
Breast cancer |
Activation |
| Uniprot ID |
|
| Interaction Name |
RELA-UPP1 interaction |
[1] |
| Studied Cell Lines |
EMT6 cell line |
| Ensembl ID |
|
| Description |
Transcription factor p65 (RELA) is reported to activate the transcription of UPP1 gene, which leads to an increased expression of the drug-metabolizing enzyme Uridine phosphorylase 1. As a result, the interaction between RELA and UPP1 can activate the drug-metabolizing process of Uridine phosphorylase 1. |
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