Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0140) | |||||
|---|---|---|---|---|---|
| DME Name | Uridine phosphorylase 2 (UPP2), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 2.4.2.3 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Multilayered rosettes embryonal tumour | Significant hypomethylation | |||
| Interaction Name | DNMT-UPP2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.79E-06; delta-beta: -6.36E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the UPP2 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Uridine phosphorylase 2. As a result, the interaction between DNMT and UPP2 can significantly affect the drug-metabolizing process of Uridine phosphorylase 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Third ventricle chordoid glioma | Significant hypermethylation | |||
| Interaction Name | DNMT-UPP2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.73E-03; delta-beta: 6.48E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the UPP2 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Uridine phosphorylase 2. As a result, the interaction between DNMT and UPP2 can significantly affect the drug-metabolizing process of Uridine phosphorylase 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B30 Lymphoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lymphoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-UPP2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 7.60E-07; delta-beta: -2.05E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the UPP2 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Uridine phosphorylase 2. As a result, the interaction between DNMT and UPP2 can moderatly affect the drug-metabolizing process of Uridine phosphorylase 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C82 Prostate cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer | Significant hypermethylation | |||
| Interaction Name | DNMT-UPP2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 4.87E-03; delta-beta: 5.01E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the UPP2 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Uridine phosphorylase 2. As a result, the interaction between DNMT and UPP2 can significantly affect the drug-metabolizing process of Uridine phosphorylase 2. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.