Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0145)
DME Name Alanyl aminopeptidase (ANPEP), Homo sapiens DME Info
UniProt ID
AMPN_HUMAN
EC Number    EC: 3.4.11.2     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Peptidase
Aminopeptidase
EC: 3.4.11.2
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2B57 Kaposi sarcoma Click to Show/Hide the Full List of HOSPPI:        2 HOSPPI
                     Transcription-factor regulation
                            Protein C-ets-1 (ETS1) Kaposi sarcoma Activation
Uniprot ID
ETS1_HUMAN
Interaction Name ETS1-ANPEP interaction [1]
Studied Cell Lines KS1767 cell line
Ensembl ID
ENSG00000134954
Description Protein C-ets-1 (ETS1) is reported to activate the transcription of ANPEP gene, which leads to an increased expression of the drug-metabolizing enzyme Alanyl aminopeptidase. As a result, the interaction between ETS1 and ANPEP can activate the drug-metabolizing process of Alanyl aminopeptidase.
                            Protein C-ets-2 (ETS2) Kaposi sarcoma Activation
Uniprot ID
ETS2_HUMAN
Interaction Name ETS2-ANPEP interaction [1]
Studied Cell Lines KS1767 cell line
Ensembl ID
ENSG00000157557
Description Protein C-ets-2 (ETS2) is reported to activate the transcription of ANPEP gene, which leads to an increased expression of the drug-metabolizing enzyme Alanyl aminopeptidase. As a result, the interaction between ETS2 and ANPEP can activate the drug-metabolizing process of Alanyl aminopeptidase.
               ICD-11: 2E81 Benign vascular neoplasm Click to Show/Hide the Full List of HOSPPI:        2 HOSPPI
                     Transcription-factor regulation
                            Protein C-ets-1 (ETS1) Benign vascular neoplasms Activation
Uniprot ID
ETS1_HUMAN
Interaction Name ETS1-ANPEP interaction [1]
Studied Cell Lines EOMA cell line
Ensembl ID
ENSG00000134954
Description Protein C-ets-1 (ETS1) is reported to activate the transcription of ANPEP gene, which leads to an increased expression of the drug-metabolizing enzyme Alanyl aminopeptidase. As a result, the interaction between ETS1 and ANPEP can activate the drug-metabolizing process of Alanyl aminopeptidase.
                            Protein C-ets-2 (ETS2) Benign vascular neoplasms Activation
Uniprot ID
ETS2_HUMAN
Interaction Name ETS2-ANPEP interaction [1]
Studied Cell Lines EOMA cell line
Ensembl ID
ENSG00000157557
Description Protein C-ets-2 (ETS2) is reported to activate the transcription of ANPEP gene, which leads to an increased expression of the drug-metabolizing enzyme Alanyl aminopeptidase. As a result, the interaction between ETS2 and ANPEP can activate the drug-metabolizing process of Alanyl aminopeptidase.
References
1 CD13/APN transcription is induced by RAS/MAPK-mediated phosphorylation of Ets-2 in activated endothelial cells. J Biol Chem. 2003 Dec 5;278(49):49358-68.

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