| General Information of Drug-Metabolizing Enzyme (DME ID: DME0146) |
| DME Name |
Phosphoglucomutase 1 (PGM1), Homo sapiens
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DME Info
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| UniProt ID |
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| EC Number |
EC: 5.4.2.2 (Click to Show/Hide the Complete EC Tree)
Isomerase
Mutase
Phosphomutase
EC: 5.4.2.2
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| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Interactome |
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| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification 02 Neoplasms |
| ICD-11: 2C25 Lung cancer |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Histone modification |
| Histone deacetylase 8 (HDAC8) |
Lung cancer |
Activation |
| Uniprot ID |
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| Interaction Name |
HDAC8-PGM1 interaction |
[1] |
| Studied Cell Lines |
Lung cancer cells |
| Description |
Histone deacetylase 8 (HDAC8) phosphorylation is reported to acetylate the PGM1 gene and thereby activates the transcriptional activity of the drug-metabolizing enzyme Phosphoglucomutase 1. As a result, the interaction between HDAC8 and PGM1 can enhance the drug-metabolizing process of Phosphoglucomutase 1. |
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| References |
| 1 |
AMPK-dependent phosphorylation of HDAC8 triggers PGM1 expression to promote lung cancer cell survival under glucose starvation. Cancer Lett. 2020 May 28;478:82-92.
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