Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0147)
DME Name	Cellular glutathione peroxidase (GPX1), Homo sapiens	DME Info
UniProt ID	GPX1_HUMAN
EC Number	EC: 1.11.1.9 (Click to Show/Hide the Complete EC Tree) Oxidoreductase Peroxidase Peroxidase EC: 1.11.1.9
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
ICD Disease Classification Healthy
ICD-11: Healthy		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Histone modification
Histone deacetylases (HDACs)		Health		Repression
Uniprot ID	HDAC1_HUMAN
Interaction Name	HDACs-GPX1 interaction				[1]
Studied Cell Lines	Rat bone marrow cells
Description	Histone deacetylases (HDACs) are reported to deacetylate the GPX1 gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme Cellular glutathione peroxidase. As a result, the interaction between HDACs and GPX1 can inhibit the drug-metabolizing process of Cellular glutathione peroxidase.
ICD Disease Classification 02 Neoplasms
ICD-11: 2A00 Brain cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Medulloblastoma		Moderate hypermethylation
Interaction Name	DNMT-GPX1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypermethylation p-value: 9.53E-25; delta-beta: 2.04E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the GPX1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Cellular glutathione peroxidase. As a result, the interaction between DNMT and GPX1 can moderatly affect the drug-metabolizing process of Cellular glutathione peroxidase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2B30 Lymphoma		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Lymphoma		Significant hypomethylation
Interaction Name	DNMT-GPX1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 7.87E-16; delta-beta: -4.76E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the GPX1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cellular glutathione peroxidase. As a result, the interaction between DNMT and GPX1 can significantly affect the drug-metabolizing process of Cellular glutathione peroxidase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2C12 Liver cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Liver cancer		Significant hypomethylation
Interaction Name	DNMT-GPX1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 4.41E-11; delta-beta: -3.20E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the GPX1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cellular glutathione peroxidase. As a result, the interaction between DNMT and GPX1 can significantly affect the drug-metabolizing process of Cellular glutathione peroxidase.
The Methylation Level of Disease Section Compare with the Adjacent Tissue	Moderate hypomethylation p-value: 2.22E-08; delta-beta: -2.99E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the GPX1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cellular glutathione peroxidase. As a result, the interaction between DNMT and GPX1 can moderatly affect the drug-metabolizing process of Cellular glutathione peroxidase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue adjacent to the diseased tissue of patients DME methylation in the normal tissue of healthy individuals DME methylation in tissue other than the diseased tissue of patients
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data of patients in the normal section of the tissue adjacent to the disease section Download DME methylation data in the tissue of healthy individual Download DME methylation data in the tissue of the other disease section
ICD-11: 2C25 Lung cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Lung cancer		Moderate hypomethylation
Interaction Name	DNMT-GPX1 interaction
The Methylation Level of Disease Section Compare with the Other Disease Section	Moderate hypomethylation p-value: 1.75E-07; delta-beta: -2.15E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the GPX1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Cellular glutathione peroxidase. As a result, the interaction between DNMT and GPX1 can moderatly affect the drug-metabolizing process of Cellular glutathione peroxidase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals DME methylation in tissue other than the diseased tissue of patients
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual Download DME methylation data in the tissue of the other disease section
ICD-11: 2C30 Melanoma		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Melanoma		Significant hypomethylation
Interaction Name	DNMT-GPX1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 1.71E-07; delta-beta: -4.12E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the GPX1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cellular glutathione peroxidase. As a result, the interaction between DNMT and GPX1 can significantly affect the drug-metabolizing process of Cellular glutathione peroxidase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2C60 Breast cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Transcription-factor regulation
TF factor AP-2 gamma (TFAP2C)		Breast cancer		Activation
Uniprot ID	AP2C_HUMAN
Interaction Name	TFAP2C-GPX1 interaction				[2]
Studied Cell Lines	MCF-7, BT-474, MDA-MB-453 and SKBR-3 cell lines
Ensembl ID	ENSG00000087510
Description	TF factor AP-2 gamma (TFAP2C) is reported to activate the transcription of GPX1 gene, which leads to an increased expression of the drug-metabolizing enzyme Cellular glutathione peroxidase. As a result, the interaction between TFAP2C and GPX1 can activate the drug-metabolizing process of Cellular glutathione peroxidase.
ICD-11: 2C73 Ovarian cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Ovarian cancer		Significant hypomethylation
Interaction Name	DNMT-GPX1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 3.20E-04; delta-beta: -3.51E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the GPX1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cellular glutathione peroxidase. As a result, the interaction between DNMT and GPX1 can significantly affect the drug-metabolizing process of Cellular glutathione peroxidase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2F7C Connective tissue cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Hemangioblastoma		Significant hypomethylation
Interaction Name	DNMT-GPX1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 2.64E-12; delta-beta: -4.36E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the GPX1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cellular glutathione peroxidase. As a result, the interaction between DNMT and GPX1 can significantly affect the drug-metabolizing process of Cellular glutathione peroxidase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2F9A Endocrine gland cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Craniopharyngioma		Significant hypomethylation
Interaction Name	DNMT-GPX1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 6.03E-18; delta-beta: -3.50E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the GPX1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Cellular glutathione peroxidase. As a result, the interaction between DNMT and GPX1 can significantly affect the drug-metabolizing process of Cellular glutathione peroxidase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases
ICD-11: 5B81 Obesity		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Obesity		Moderate hypermethylation
Interaction Name	DNMT-GPX1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypermethylation p-value: 4.14E-02; delta-beta: 2.14E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the GPX1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Cellular glutathione peroxidase. As a result, the interaction between DNMT and GPX1 can moderatly affect the drug-metabolizing process of Cellular glutathione peroxidase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual

References
1	Potential anti-genotoxic effect of sodium butyrate to modulate induction of DNA damage by tamoxifen citrate in rat bone marrow cells. Cytotechnology. 2017 Feb;69(1):89-102.
2	Transcriptional regulation of the GPX1 gene by TFAP2C and aberrant CpG methylation in human breast cancer. Oncogene. 2013 Aug 22;32(34):4043-51.

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