| General Information of Drug-Metabolizing Enzyme (DME ID: DME0149) |
| DME Name |
Vitamin K1 2,3-epoxide reductase 1 (VKOR), Homo sapiens
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DME Info
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| UniProt ID |
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| EC Number |
EC: 1.17.4.4 (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
CH/CH2 oxidoreductase
Disulfide acceptor oxidoreductase
EC: 1.17.4.4
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| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Interactome |
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| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification 02 Neoplasms |
| ICD-11: 2C12 Liver cancer |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Non-coding RNA regulation |
| hsa-miR-133a-3p |
Liver cancer |
Suppression |
| miRBase ID |
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| Interaction Name |
hsa-miR-133a-3p--VKORC1 regulation |
[1] |
| Studied Cell Lines |
HepG2 cell line |
| Description |
hsa-miR-133a-3p is reported to suppress VKORC1 mRNA translation by binding to the 3' untranslated region (3'UTR) of VKORC1 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Vitamin K1 2,3-epoxide reductase 1. |
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| References |
| 1 |
miR-133a regulates vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1), a key protein in the vitamin K cycle. Mol Med. 2013 Jan 22;18(1):1466-72.
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