Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0151)
DME Name Phosphorylcholine transferase A (PCYT1A), Homo sapiens DME Info
UniProt ID
PCY1A_HUMAN
EC Number    EC: 2.7.7.15     (Click to Show/Hide the Complete EC Tree)
Transferase
Kinase
Nucleotidyltransferase
EC: 2.7.7.15
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2C12 Liver cancer Click to Show/Hide the Full List of HOSPPI:        2 HOSPPI
                     Transcription-factor regulation
                            Zinc finger 143 (ZNF143) Liver cancer Activation
Uniprot ID
ZN143_HUMAN
Interaction Name ZNF143-PCYT1A interaction [1]
Studied Cell Lines HepG2 cell line
Ensembl ID
ENSG00000166478
Description Zinc finger 143 (ZNF143) is reported to activate the transcription of PCYT1A gene, which leads to an increased expression of the drug-metabolizing enzyme Phosphorylcholine transferase A. As a result, the interaction between ZNF143 and PCYT1A can activate the drug-metabolizing process of Phosphorylcholine transferase A.
                            Zinc finger protein 76 (ZNF76) Liver cancer Activation
Uniprot ID
ZNF76_HUMAN
Interaction Name ZNF76-PCYT1A interaction [1]
Studied Cell Lines HepG2 cell line
Ensembl ID
ENSG00000065029
Description Zinc finger protein 76 (ZNF76) is reported to activate the transcription of PCYT1A gene, which leads to an increased expression of the drug-metabolizing enzyme Phosphorylcholine transferase A. As a result, the interaction between ZNF76 and PCYT1A can activate the drug-metabolizing process of Phosphorylcholine transferase A.
               ICD-11: 2C77 Cervical cancer Click to Show/Hide the Full List of HOSPPI:        2 HOSPPI
                     Transcription-factor regulation
                            Zinc finger 143 (ZNF143) Cervical cancer Activation
Uniprot ID
ZN143_HUMAN
Interaction Name ZNF143-PCYT1A interaction [1]
Studied Cell Lines HeLa cell line
Ensembl ID
ENSG00000166478
Description Zinc finger 143 (ZNF143) is reported to activate the transcription of PCYT1A gene, which leads to an increased expression of the drug-metabolizing enzyme Phosphorylcholine transferase A. As a result, the interaction between ZNF143 and PCYT1A can activate the drug-metabolizing process of Phosphorylcholine transferase A.
                            Zinc finger protein 76 (ZNF76) Cervical cancer Activation
Uniprot ID
ZNF76_HUMAN
Interaction Name ZNF76-PCYT1A interaction [1]
Studied Cell Lines HeLa cell line
Ensembl ID
ENSG00000065029
Description Zinc finger protein 76 (ZNF76) is reported to activate the transcription of PCYT1A gene, which leads to an increased expression of the drug-metabolizing enzyme Phosphorylcholine transferase A. As a result, the interaction between ZNF76 and PCYT1A can activate the drug-metabolizing process of Phosphorylcholine transferase A.
References
1 ZNF143 mediates basal and tissue-specific expression of human transaldolase. J Biol Chem. 2004 Mar 26;279(13):12190-205.

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