| General Information of Drug-Metabolizing Enzyme (DME ID: DME0152) |
| DME Name |
Phosphorylethanolamine transferase (PCYT2), Homo sapiens
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DME Info
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| UniProt ID |
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| EC Number |
EC: 2.7.7.14 (Click to Show/Hide the Complete EC Tree)
Transferase
Kinase
Nucleotidyltransferase
EC: 2.7.7.14
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| Lineage |
Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
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| Interactome |
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| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification Healthy |
| ICD-11: Healthy |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Histone modification |
| Histone acetyltransferases (HATs) |
Health |
Activation |
| Uniprot ID |
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| Interaction Name |
HATs-PCYT2 interaction |
[1] |
| Studied Cell Lines |
Transferred cell line |
| Description |
Histone acetyltransferases (HATs) are reported to acetylate the PCYT2 gene and thereby activate the transcriptional activity of the drug-metabolizing enzyme Phosphorylethanolamine transferase. As a result, the interaction between HATs and PCYT2 can enhance the drug-metabolizing process of Phosphorylethanolamine transferase. |
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| References |
| 1 |
Side-chain oxysterols suppress the transcription of CTP: Phosphoethanolamine cytidylyltransferase and 3-hydroxy-3-methylglutaryl-CoA reductase by inhibiting the interaction of p300 and NF-Y, and H3K27 acetylation. J Steroid Biochem Mol Biol. 2019 Dec;195:105482.
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