| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification 08 Nervous system diseases |
| ICD-11: 8A20 Alzheimer disease |
Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
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| Transcription-factor regulation |
| Amyloid-beta A4 binding B1 (APBB1) |
Alzheimer disease |
Repression |
| Uniprot ID |
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| Interaction Name |
APBB1-GMPS interaction |
[1] |
| Studied Cell Lines |
Alzheimer frontal cortex brain samples |
| Description |
Amyloid-beta A4 binding B1 (APBB1) is reported to repress the transcription of GMPS gene, which leads to a decreased expression of the drug-metabolizing enzyme Glutamine amidotransferase. As a result, the interaction between APBB1 and GMPS can repress the drug-metabolizing process of Glutamine amidotransferase. |
| Lysine acetyltransferase 5 (KAT5) |
Alzheimer disease |
Repression |
| Uniprot ID |
|
| Interaction Name |
KAT5-GMPS interaction |
[1] |
| Studied Cell Lines |
Frontal cortex brain cell line |
| Description |
Lysine acetyltransferase 5 (KAT5) is reported to repress the transcription of GMPS gene, which leads to a decreased expression of the drug-metabolizing enzyme Glutamine amidotransferase. As a result, the interaction between KAT5 and GMPS can repress the drug-metabolizing process of Glutamine amidotransferase. |
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