| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification 02 Neoplasms |
| ICD-11: 2A00 Brain cancer |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Histone modification |
| Histone deacetylases (HDACs) |
Glioblastoma |
Repression |
| Uniprot ID |
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| Interaction Name |
HDACs-TGM2 interaction |
[1] |
| Studied Cell Lines |
Glioma cells |
| Description |
Histone deacetylases (HDACs) are reported to deacetylate the TGM2 gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme Transglutaminase H. As a result, the interaction between HDACs and TGM2 can inhibit the drug-metabolizing process of Transglutaminase H. |
| ICD-11: 2C90 Renal cell carcinoma |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
|
| Non-coding RNA regulation |
| hsa-miR-1285-3p |
Renal cell carcinoma |
Suppression |
| miRBase ID |
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| Interaction Name |
hsa-miR-1285-3p--TGM2 regulation |
[2] |
| Studied Cell Lines |
A498, 786-O, ACHN and caki-2 cell lines |
| Description |
hsa-miR-1285-3p is reported to suppress TGM2 mRNA translation by binding to the 3' untranslated region (3'UTR) of TGM2 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Transglutaminase H. |
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