Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0165) | |||||
|---|---|---|---|---|---|
| DME Name | Transglutaminase E (TGM3), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 2.3.2.13 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 12 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Low grade glioma | Moderate hypomethylation | |||
| Interaction Name | DNMT-TGM3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.08E-08; delta-beta: -2.41E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the TGM3 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Transglutaminase E. As a result, the interaction between DNMT and TGM3 can moderatly affect the drug-metabolizing process of Transglutaminase E. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-TGM3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.14E-13; delta-beta: -4.53E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the TGM3 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Transglutaminase E. As a result, the interaction between DNMT and TGM3 can significantly affect the drug-metabolizing process of Transglutaminase E. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Malignant astrocytoma | Significant hypomethylation | |||
| Interaction Name | DNMT-TGM3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 7.62E-20; delta-beta: -3.43E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the TGM3 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Transglutaminase E. As a result, the interaction between DNMT and TGM3 can significantly affect the drug-metabolizing process of Transglutaminase E. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Brain neuroepithelial tumour | Moderate hypermethylation | |||
| Interaction Name | DNMT-TGM3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 1.86E-09; delta-beta: 2.65E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the TGM3 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Transglutaminase E. As a result, the interaction between DNMT and TGM3 can moderatly affect the drug-metabolizing process of Transglutaminase E. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Central neurocytoma | Significant hypomethylation | |||
| Interaction Name | DNMT-TGM3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 7.46E-07; delta-beta: -5.17E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the TGM3 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Transglutaminase E. As a result, the interaction between DNMT and TGM3 can significantly affect the drug-metabolizing process of Transglutaminase E. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Myxopapillary ependymoma | Moderate hypermethylation | |||
| Interaction Name | DNMT-TGM3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 4.88E-02; delta-beta: 2.03E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the TGM3 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Transglutaminase E. As a result, the interaction between DNMT and TGM3 can moderatly affect the drug-metabolizing process of Transglutaminase E. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Cerebellar liponeurocytoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-TGM3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.84E-04; delta-beta: -2.70E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the TGM3 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Transglutaminase E. As a result, the interaction between DNMT and TGM3 can moderatly affect the drug-metabolizing process of Transglutaminase E. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Diffuse midline glioma | Significant hypomethylation | |||
| Interaction Name | DNMT-TGM3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.98E-26; delta-beta: -3.93E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the TGM3 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Transglutaminase E. As a result, the interaction between DNMT and TGM3 can significantly affect the drug-metabolizing process of Transglutaminase E. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Third ventricle chordoid glioma | Significant hypermethylation | |||
| Interaction Name | DNMT-TGM3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 2.87E-03; delta-beta: 4.11E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the TGM3 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Transglutaminase E. As a result, the interaction between DNMT and TGM3 can significantly affect the drug-metabolizing process of Transglutaminase E. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Spinal ependymoma | Significant hypermethylation | |||
| Interaction Name | DNMT-TGM3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 8.73E-12; delta-beta: 5.41E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the TGM3 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Transglutaminase E. As a result, the interaction between DNMT and TGM3 can significantly affect the drug-metabolizing process of Transglutaminase E. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Oligodendroglioma | Moderate hypomethylation | |||
| Interaction Name | DNMT-TGM3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 6.37E-06; delta-beta: -2.32E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the TGM3 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Transglutaminase E. As a result, the interaction between DNMT and TGM3 can moderatly affect the drug-metabolizing process of Transglutaminase E. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Atypical teratoid/rhabdoid tumour | Significant hypermethylation | |||
| Interaction Name | DNMT-TGM3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.86E-11; delta-beta: 3.70E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the TGM3 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Transglutaminase E. As a result, the interaction between DNMT and TGM3 can significantly affect the drug-metabolizing process of Transglutaminase E. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2A01 Meningeal tumour | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Meningioma | Moderate hypermethylation | |||
| Interaction Name | DNMT-TGM3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 3.44E-18; delta-beta: 2.09E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the TGM3 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Transglutaminase E. As a result, the interaction between DNMT and TGM3 can moderatly affect the drug-metabolizing process of Transglutaminase E. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B90 Colorectal cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Colorectal cancer | Moderate hypermethylation | |||
| Interaction Name | DNMT-TGM3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Moderate hypermethylation p-value: 2.08E-03; delta-beta: 2.27E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the TGM3 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Transglutaminase E. As a result, the interaction between DNMT and TGM3 can moderatly affect the drug-metabolizing process of Transglutaminase E. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C25 Lung cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lung cancer | Moderate hypomethylation | |||
| Interaction Name | DNMT-TGM3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 3.62E-24; delta-beta: -2.75E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the TGM3 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Transglutaminase E. As a result, the interaction between DNMT and TGM3 can moderatly affect the drug-metabolizing process of Transglutaminase E. | ||||
| The Methylation Level of Disease Section Compare with the Other Disease Section | Moderate hypomethylation p-value: 4.34E-21; delta-beta: -2.80E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the TGM3 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Transglutaminase E. As a result, the interaction between DNMT and TGM3 can moderatly affect the drug-metabolizing process of Transglutaminase E. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
DME methylation in tissue other than the diseased tissue of patients
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C82 Prostate cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer | Significant hypermethylation | |||
| Interaction Name | DNMT-TGM3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.51E-04; delta-beta: 3.01E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the TGM3 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Transglutaminase E. As a result, the interaction between DNMT and TGM3 can significantly affect the drug-metabolizing process of Transglutaminase E. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases | |||||
| ICD-11: 5B81 Obesity | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Obesity | Moderate hypomethylation | |||
| Interaction Name | DNMT-TGM3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 6.74E-16; delta-beta: -2.92E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the TGM3 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Transglutaminase E. As a result, the interaction between DNMT and TGM3 can moderatly affect the drug-metabolizing process of Transglutaminase E. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 11 Circulatory system diseases | |||||
| ICD-11: BD51 Arterial aneurysm | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Arterial aneurysm | Significant hypermethylation | |||
| Interaction Name | DNMT-TGM3 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 8.73E-03; delta-beta: 4.14E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the TGM3 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Transglutaminase E. As a result, the interaction between DNMT and TGM3 can significantly affect the drug-metabolizing process of Transglutaminase E. | ||||
| The Methylation Level of Disease Section Compare with the Adjacent Tissue | Significant hypermethylation p-value: 1.44E-02; delta-beta: 3.00E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the TGM3 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Transglutaminase E. As a result, the interaction between DNMT and TGM3 can significantly affect the drug-metabolizing process of Transglutaminase E. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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