Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0166)
DME Name	Transglutaminase K (TGM1), Homo sapiens	DME Info
UniProt ID	TGM1_HUMAN
EC Number	EC: 2.3.2.13 (Click to Show/Hide the Complete EC Tree) Transferase Acyltransferase Aminoacyltransferase EC: 2.3.2.13
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
ICD Disease Classification Healthy
ICD-11: Healthy		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Histone modification
Histone deacetylase 3 (HDAC3)		Health		Repression
Uniprot ID	HDAC3_HUMAN
Interaction Name	HDAC3-TGM1 interaction				[1]
Studied Cell Lines	Basal cells
Description	Histone deacetylase 3 (HDAC3) is reported to deacetylate the TGM1 gene and thereby represses the transcriptional activity of the drug-metabolizing enzyme Transglutaminase K. As a result, the interaction between HDAC3 and TGM1 can inhibit the drug-metabolizing process of Transglutaminase K.
ICD Disease Classification 02 Neoplasms
ICD-11: 2A00 Brain cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Brain neuroblastoma		Moderate hypomethylation
Interaction Name	DNMT-TGM1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 1.01E-20; delta-beta: -2.22E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the TGM1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Transglutaminase K. As a result, the interaction between DNMT and TGM1 can moderatly affect the drug-metabolizing process of Transglutaminase K.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2B30 Lymphoma		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Lymphoma		Moderate hypomethylation
Interaction Name	DNMT-TGM1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 4.94E-07; delta-beta: -2.28E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the TGM1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Transglutaminase K. As a result, the interaction between DNMT and TGM1 can moderatly affect the drug-metabolizing process of Transglutaminase K.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases
ICD-11: 5B81 Obesity		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Obesity		Moderate hypomethylation
Interaction Name	DNMT-TGM1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 1.02E-17; delta-beta: -2.12E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the TGM1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Transglutaminase K. As a result, the interaction between DNMT and TGM1 can moderatly affect the drug-metabolizing process of Transglutaminase K.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual

References
1	HDAC3 ensures stepwise epidermal stratification via NCoR/SMRT-reliant mechanisms independent of its histone deacetylase activity. Genes Dev. 2020 Jul 1;34(13-14):973-988.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.