| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification Healthy |
| ICD-11: Healthy |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Transcription-factor regulation |
| Proto-oncogene c-Myc (MYC) |
Health |
Activation |
| Uniprot ID |
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| Interaction Name |
MYC-MME interaction |
[1] |
| Studied Cell Lines |
EREB2-5 cell line |
| Ensembl ID |
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| Description |
Proto-oncogene c-Myc (MYC) is reported to activate the transcription of MME gene, which leads to an increased expression of the drug-metabolizing enzyme Neprilysin. As a result, the interaction between MYC and MME can activate the drug-metabolizing process of Neprilysin. |
| ICD Disease Classification 02 Neoplasms |
| ICD-11: 2C82 Prostate cancer |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Transcription-factor regulation |
| Homeobox protein Hox-C6 (HOXC6) |
Prostate cancer |
Repression |
| Uniprot ID |
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| Interaction Name |
HOXC6-MME interaction |
[2] |
| Studied Cell Lines |
LnCaP, C4-2, DU145, and PC3 PCa cell lines |
| Ensembl ID |
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| Description |
Homeobox protein Hox-C6 (HOXC6) is reported to repress the transcription of MME gene, which leads to a decreased expression of the drug-metabolizing enzyme Neprilysin. As a result, the interaction between HOXC6 and MME can repress the drug-metabolizing process of Neprilysin. |
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