Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0171)
DME Name Indoleamine 2,3-dioxygenase 1 (IDO1), Homo sapiens DME Info
UniProt ID
I23O1_HUMAN
EC Number    EC: 1.13.11.52     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen single donor oxidoreductase
Oxygen single donor oxidoreductase
EC: 1.13.11.52
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification 02 Neoplasms
               ICD-11: 3A70 Aplastic anemia Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Transcription-factor regulation
                            Prothymosin alpha (PTMA) Aplastic anemia Activation
Uniprot ID
PTMA_HUMAN
Interaction Name PTMA-IDO1 interaction [1], [2]
Studied Cell Lines Mesenchymal stem cell line
Description Prothymosin alpha (PTMA) is reported to activate the transcription of IDO1 gene, which leads to an increased expression of the drug-metabolizing enzyme Indoleamine 2,3-dioxygenase 1. As a result, the interaction between PTMA and IDO1 can activate the drug-metabolizing process of Indoleamine 2,3-dioxygenase 1.
      ICD Disease Classification 04 Immune system diseases
               ICD-11: 4B24 Graft-versus-host disease Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Non-coding RNA regulation
                            hsa-miR-153-3p Graft-versus-host disease Suppression
miRBase ID
MIMAT0000439
Interaction Name hsa-miR-153-3p--IDO1 regulation [3]
Studied Cell Lines Graft-versus-host disease cells
Description hsa-miR-153-3p is reported to suppress IDO1 mRNA translation by binding to the 3' untranslated region (3'UTR) of IDO1 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Indoleamine 2,3-dioxygenase 1.
References
1 Regulatory effect of thymosin alpha1 on expression of tlr9/ido mRNA in bone marrow mesenchymal stem cells from children with aplastic anemia. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010 Dec;18(6):1564-7.
2 An experimental study on the regulation of bone marrow-derived mesenchymal stem cells through indoleamine 2,3-dioxygenase signaling pathway by thymosin alpha1 for improving the immunosuppression mediated by T cell. Zhonghua Er Ke Za Zhi. 2011 Mar;49(3):181-5.
3 miR-153-3p, a new bio-target, is involved in the pathogenesis of acute graft-versus-host disease via inhibition of indoleamine- 2,3-dioxygenase. Oncotarget. 2016 Jul 26;7(30):48321-48334.

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