| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification 02 Neoplasms |
| ICD-11: 3A70 Aplastic anemia |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Transcription-factor regulation |
| Prothymosin alpha (PTMA) |
Aplastic anemia |
Activation |
| Uniprot ID |
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| Interaction Name |
PTMA-IDO1 interaction |
[1], [2] |
| Studied Cell Lines |
Mesenchymal stem cell line |
| Description |
Prothymosin alpha (PTMA) is reported to activate the transcription of IDO1 gene, which leads to an increased expression of the drug-metabolizing enzyme Indoleamine 2,3-dioxygenase 1. As a result, the interaction between PTMA and IDO1 can activate the drug-metabolizing process of Indoleamine 2,3-dioxygenase 1. |
| ICD Disease Classification 04 Immune system diseases |
| ICD-11: 4B24 Graft-versus-host disease |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
|
| Non-coding RNA regulation |
| hsa-miR-153-3p |
Graft-versus-host disease |
Suppression |
| miRBase ID |
|
| Interaction Name |
hsa-miR-153-3p--IDO1 regulation |
[3] |
| Studied Cell Lines |
Graft-versus-host disease cells |
| Description |
hsa-miR-153-3p is reported to suppress IDO1 mRNA translation by binding to the 3' untranslated region (3'UTR) of IDO1 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Indoleamine 2,3-dioxygenase 1. |
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