Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0172) | |||||
|---|---|---|---|---|---|
| DME Name | Tryptophan oxygenase (TRPO), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 1.13.11.11 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 12 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Glioblastoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-TRPO interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 6.26E-06; delta-beta: -2.06E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the TRPO gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Tryptophan oxygenase. As a result, the interaction between DNMT and TRPO can moderatly affect the drug-metabolizing process of Tryptophan oxygenase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Anaplastic pilocytic astrocytoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-TRPO interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 3.11E-04; delta-beta: -2.09E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the TRPO gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Tryptophan oxygenase. As a result, the interaction between DNMT and TRPO can moderatly affect the drug-metabolizing process of Tryptophan oxygenase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Significant hypomethylation | |||
| Interaction Name | DNMT-TRPO interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.98E-14; delta-beta: -4.83E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the TRPO gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Tryptophan oxygenase. As a result, the interaction between DNMT and TRPO can significantly affect the drug-metabolizing process of Tryptophan oxygenase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Malignant astrocytoma | Significant hypomethylation | |||
| Interaction Name | DNMT-TRPO interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 9.44E-24; delta-beta: -3.09E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the TRPO gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Tryptophan oxygenase. As a result, the interaction between DNMT and TRPO can significantly affect the drug-metabolizing process of Tryptophan oxygenase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Oligodendroglial tumour | Significant hypomethylation | |||
| Interaction Name | DNMT-TRPO interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.08E-02; delta-beta: -3.71E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the TRPO gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Tryptophan oxygenase. As a result, the interaction between DNMT and TRPO can significantly affect the drug-metabolizing process of Tryptophan oxygenase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Melanocytoma | Significant hypermethylation | |||
| Interaction Name | DNMT-TRPO interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.61E-06; delta-beta: 3.16E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the TRPO gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Tryptophan oxygenase. As a result, the interaction between DNMT and TRPO can significantly affect the drug-metabolizing process of Tryptophan oxygenase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Multilayered rosettes embryonal tumour | Moderate hypomethylation | |||
| Interaction Name | DNMT-TRPO interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 8.32E-05; delta-beta: -2.01E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the TRPO gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Tryptophan oxygenase. As a result, the interaction between DNMT and TRPO can moderatly affect the drug-metabolizing process of Tryptophan oxygenase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Cerebellar liponeurocytoma | Significant hypomethylation | |||
| Interaction Name | DNMT-TRPO interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.71E-04; delta-beta: -4.13E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the TRPO gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Tryptophan oxygenase. As a result, the interaction between DNMT and TRPO can significantly affect the drug-metabolizing process of Tryptophan oxygenase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Diffuse midline glioma | Significant hypomethylation | |||
| Interaction Name | DNMT-TRPO interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 9.91E-41; delta-beta: -4.59E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the TRPO gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Tryptophan oxygenase. As a result, the interaction between DNMT and TRPO can significantly affect the drug-metabolizing process of Tryptophan oxygenase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Third ventricle chordoid glioma | Moderate hypermethylation | |||
| Interaction Name | DNMT-TRPO interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 3.03E-05; delta-beta: 2.94E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the TRPO gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Tryptophan oxygenase. As a result, the interaction between DNMT and TRPO can moderatly affect the drug-metabolizing process of Tryptophan oxygenase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Spinal ependymoma | Significant hypermethylation | |||
| Interaction Name | DNMT-TRPO interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.84E-07; delta-beta: 3.69E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the TRPO gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Tryptophan oxygenase. As a result, the interaction between DNMT and TRPO can significantly affect the drug-metabolizing process of Tryptophan oxygenase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Oligodendroglioma | Moderate hypomethylation | |||
| Interaction Name | DNMT-TRPO interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.44E-13; delta-beta: -2.90E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the TRPO gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Tryptophan oxygenase. As a result, the interaction between DNMT and TRPO can moderatly affect the drug-metabolizing process of Tryptophan oxygenase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B30 Lymphoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lymphoma | Significant hypomethylation | |||
| Interaction Name | DNMT-TRPO interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.54E-13; delta-beta: -4.08E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the TRPO gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Tryptophan oxygenase. As a result, the interaction between DNMT and TRPO can significantly affect the drug-metabolizing process of Tryptophan oxygenase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C82 Prostate cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer | Significant hypermethylation | |||
| Interaction Name | DNMT-TRPO interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.70E-04; delta-beta: 5.38E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the TRPO gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Tryptophan oxygenase. As a result, the interaction between DNMT and TRPO can significantly affect the drug-metabolizing process of Tryptophan oxygenase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2D50 Brain cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Esthesioneuroblastoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-TRPO interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 4.55E-05; delta-beta: -2.36E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the TRPO gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Tryptophan oxygenase. As a result, the interaction between DNMT and TRPO can moderatly affect the drug-metabolizing process of Tryptophan oxygenase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Posterior fossa ependymoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-TRPO interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.66E-30; delta-beta: -2.92E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the TRPO gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Tryptophan oxygenase. As a result, the interaction between DNMT and TRPO can moderatly affect the drug-metabolizing process of Tryptophan oxygenase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2F37 Endocrine gland cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Pituitary adenoma | Moderate hypermethylation | |||
| Interaction Name | DNMT-TRPO interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 6.51E-04; delta-beta: 2.97E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the TRPO gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Tryptophan oxygenase. As a result, the interaction between DNMT and TRPO can moderatly affect the drug-metabolizing process of Tryptophan oxygenase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2F7C Connective tissue cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Hemangioblastoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-TRPO interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 3.53E-04; delta-beta: -2.31E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the TRPO gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Tryptophan oxygenase. As a result, the interaction between DNMT and TRPO can moderatly affect the drug-metabolizing process of Tryptophan oxygenase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases | |||||
| ICD-11: 5A61 Pituitary gland hypofunction | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Chordoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-TRPO interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 2.20E-02; delta-beta: -2.80E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the TRPO gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Tryptophan oxygenase. As a result, the interaction between DNMT and TRPO can moderatly affect the drug-metabolizing process of Tryptophan oxygenase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 12 Respiratory system diseases | |||||
| ICD-11: CA23 Asthma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Asthma | Significant hypermethylation | |||
| Interaction Name | DNMT-TRPO interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 5.51E-03; delta-beta: 3.14E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the TRPO gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Tryptophan oxygenase. As a result, the interaction between DNMT and TRPO can significantly affect the drug-metabolizing process of Tryptophan oxygenase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: CB03 Idiopathic pulmonary fibrosis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Idiopathic pulmonary fibrosis | Significant hypomethylation | |||
| Interaction Name | DNMT-TRPO interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 3.03E-02; delta-beta: -3.28E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the TRPO gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Tryptophan oxygenase. As a result, the interaction between DNMT and TRPO can significantly affect the drug-metabolizing process of Tryptophan oxygenase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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