Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0173)
DME Name Tryptophan 5-hydroxylase 1 (TPH1), Homo sapiens DME Info
UniProt ID
TPH1_HUMAN
EC Number    EC: 1.14.16.4     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen paired donor oxidoreductase
Pteridine donor oxidoreductase
EC: 1.14.16.4
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification Healthy
               ICD-11: Healthy Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Histone modification
                            Histone deacetylases (HDACs) Health Repression
Uniprot ID
HDAC1_HUMAN
Interaction Name HDACs-TPH1 interaction [1]
Studied Cell Lines Rat islets cell
Description Histone deacetylases (HDACs) are reported to deacetylate the TPH1 gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme Tryptophan 5-hydroxylase 1. As a result, the interaction between HDACs and TPH1 can inhibit the drug-metabolizing process of Tryptophan 5-hydroxylase 1.
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2C10 Pancreatic cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Transcription-factor regulation
                            Achaete-scute homolog 1 (ASCL1) Pancreatic endocrine tumour Repression
Uniprot ID
ASCL1_HUMAN
Interaction Name ASCL1-TPH1 interaction [2]
Studied Cell Lines BON1 cell line
Ensembl ID
ENSG00000139352
Description Achaete-scute homolog 1 (ASCL1) is reported to repress the transcription of TPH1 gene, which leads to a decreased expression of the drug-metabolizing enzyme Tryptophan 5-hydroxylase 1. As a result, the interaction between ASCL1 and TPH1 can repress the drug-metabolizing process of Tryptophan 5-hydroxylase 1.
               ICD-11: 2C77 Cervical cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Transcription-factor regulation
                            Nuclear TF factor Y beta (NFYB) Cervical cancer Activation
Uniprot ID
NFYB_HUMAN
Interaction Name NFYB-TPH1 interaction [3]
Studied Cell Lines HeLa cell line
Ensembl ID
ENSG00000120837
Description Nuclear TF factor Y beta (NFYB) is reported to activate the transcription of TPH1 gene, which leads to an increased expression of the drug-metabolizing enzyme Tryptophan 5-hydroxylase 1. As a result, the interaction between NFYB and TPH1 can activate the drug-metabolizing process of Tryptophan 5-hydroxylase 1.
References
1 Protein acetylation derepresses Serotonin Synthesis to potentiate Pancreatic Beta-Cell Function through HDAC1-PKA-Tph1 signaling. Theranostics. 2020 Jun 5;10(16):7351-7368.
2 Identification of Achaete-scute complex-like 1 (ASCL1) target genes and evaluation of DKK1 and TPH1 expression in pancreatic endocrine tumours. BMC Cancer. 2009 Sep 10;9:321.
3 CBF/NF-Y activates transcription of the human tryptophan hydroxylase gene through an inverted CCAAT box. Brain Res Mol Brain Res. 1998 Mar 30;55(1):61-70.

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