| Disease Specific Interactions between Host Protein and DME (HOSPPI) |
| ICD Disease Classification Healthy |
| ICD-11: Healthy |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
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| Histone modification |
| Histone deacetylases (HDACs) |
Health |
Repression |
| Uniprot ID |
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| Interaction Name |
HDACs-TPH2 interaction |
[1] |
| Studied Cell Lines |
RN46A cells |
| Description |
Histone deacetylases (HDACs) are reported to deacetylate the TPH2 gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme Tryptophan 5-hydroxylase 2. As a result, the interaction between HDACs and TPH2 can inhibit the drug-metabolizing process of Tryptophan 5-hydroxylase 2. |
| ICD Disease Classification 02 Neoplasms |
| ICD-11: 2A00 Brain cancer |
Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
|
| Transcription-factor regulation |
| X2 box repressor (REST) |
Glioblastoma |
Activation |
| Uniprot ID |
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| Interaction Name |
REST-TPH2 interaction |
[2] |
| Studied Cell Lines |
C6-glioma cell line |
| Ensembl ID |
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| Description |
X2 box repressor (REST) is reported to activate the transcription of TPH2 gene, which leads to an increased expression of the drug-metabolizing enzyme Tryptophan 5-hydroxylase 2. As a result, the interaction between REST and TPH2 can activate the drug-metabolizing process of Tryptophan 5-hydroxylase 2. |
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