General Information of Drug-Metabolizing Enzyme (DME ID: DME0176)
DME Name Tryptophanyl-tRNA synthetase mitochondrial (WARS2), Homo sapiens DME Info
UniProt ID
SYWM_HUMAN
EC Number    EC: 6.1.1.2     (Click to Show/Hide the Complete EC Tree)
Ligase
Carbon-oxygen ligase
Aminoacyl tRNA synthetase
EC: 6.1.1.2
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2A00 Brain cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Brain neuroblastoma Significant hypomethylation
Interaction Name DNMT-WARS2 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Significant hypomethylation
p-value: 1.69E-10; delta-beta: -3.10E-01
Description DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the WARS2 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Tryptophanyl-tRNA synthetase mitochondrial. As a result, the interaction between DNMT and WARS2 can significantly affect the drug-metabolizing process of Tryptophanyl-tRNA synthetase mitochondrial.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram

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