Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0177) | |||||
|---|---|---|---|---|---|
| DME Name | Cytosolic branched aminotransferase (BCAT1), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 2.6.1.42 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 4 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Brain neuroepithelial tumour | Moderate hypermethylation | |||
| Interaction Name | DNMT-BCAT1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 1.67E-10; delta-beta: 2.17E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the BCAT1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Cytosolic branched aminotransferase. As a result, the interaction between DNMT and BCAT1 can moderatly affect the drug-metabolizing process of Cytosolic branched aminotransferase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Oligodendroglial tumour | Moderate hypermethylation | |||
| Interaction Name | DNMT-BCAT1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 1.83E-06; delta-beta: 2.93E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the BCAT1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Cytosolic branched aminotransferase. As a result, the interaction between DNMT and BCAT1 can moderatly affect the drug-metabolizing process of Cytosolic branched aminotransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Melanocytoma | Significant hypermethylation | |||
| Interaction Name | DNMT-BCAT1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 5.48E-10; delta-beta: 5.30E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the BCAT1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Cytosolic branched aminotransferase. As a result, the interaction between DNMT and BCAT1 can significantly affect the drug-metabolizing process of Cytosolic branched aminotransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Oligodendroglioma | Significant hypermethylation | |||
| Interaction Name | DNMT-BCAT1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.19E-40; delta-beta: 4.60E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the BCAT1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Cytosolic branched aminotransferase. As a result, the interaction between DNMT and BCAT1 can significantly affect the drug-metabolizing process of Cytosolic branched aminotransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2A01 Meningeal tumour | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Meningioma | Moderate hypermethylation | |||
| Interaction Name | DNMT-BCAT1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 1.38E-21; delta-beta: 2.14E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the BCAT1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Cytosolic branched aminotransferase. As a result, the interaction between DNMT and BCAT1 can moderatly affect the drug-metabolizing process of Cytosolic branched aminotransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C25 Lung cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lung cancer | Significant hypermethylation | |||
| Interaction Name | DNMT-BCAT1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Other Disease Section | Significant hypermethylation p-value: 5.41E-06; delta-beta: 9.06E-02 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the BCAT1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Cytosolic branched aminotransferase. As a result, the interaction between DNMT and BCAT1 can significantly affect the drug-metabolizing process of Cytosolic branched aminotransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
DME methylation in tissue other than the diseased tissue of patients
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C30 Melanoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Melanoma | Significant hypermethylation | |||
| Interaction Name | DNMT-BCAT1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 4.78E-06; delta-beta: 4.63E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the BCAT1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Cytosolic branched aminotransferase. As a result, the interaction between DNMT and BCAT1 can significantly affect the drug-metabolizing process of Cytosolic branched aminotransferase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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