Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0187) | |||||
|---|---|---|---|---|---|
| DME Name | Methionine-tRNA ligase mitochondrial (MARS2), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 6.1.1.10 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Central neurocytoma | Significant hypomethylation | |||
| Interaction Name | DNMT-MARS2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 4.74E-05; delta-beta: -3.05E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the MARS2 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Methionine-tRNA ligase mitochondrial. As a result, the interaction between DNMT and MARS2 can significantly affect the drug-metabolizing process of Methionine-tRNA ligase mitochondrial. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Diffuse midline glioma | Moderate hypomethylation | |||
| Interaction Name | DNMT-MARS2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.56E-19; delta-beta: -2.01E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the MARS2 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Methionine-tRNA ligase mitochondrial. As a result, the interaction between DNMT and MARS2 can moderatly affect the drug-metabolizing process of Methionine-tRNA ligase mitochondrial. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2B30 Lymphoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Lymphoma | Significant hypomethylation | |||
| Interaction Name | DNMT-MARS2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 2.85E-09; delta-beta: -3.50E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the MARS2 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Methionine-tRNA ligase mitochondrial. As a result, the interaction between DNMT and MARS2 can significantly affect the drug-metabolizing process of Methionine-tRNA ligase mitochondrial. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C30 Melanoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Melanoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-MARS2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.17E-03; delta-beta: -2.17E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the MARS2 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Methionine-tRNA ligase mitochondrial. As a result, the interaction between DNMT and MARS2 can moderatly affect the drug-metabolizing process of Methionine-tRNA ligase mitochondrial. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C82 Prostate cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer | Moderate hypermethylation | |||
| Interaction Name | DNMT-MARS2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 2.66E-02; delta-beta: 2.72E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the MARS2 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Methionine-tRNA ligase mitochondrial. As a result, the interaction between DNMT and MARS2 can moderatly affect the drug-metabolizing process of Methionine-tRNA ligase mitochondrial. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2E06 Prostate cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer metastasis | Moderate hypomethylation | |||
| Interaction Name | DNMT-MARS2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.14E-02; delta-beta: -2.67E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the MARS2 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Methionine-tRNA ligase mitochondrial. As a result, the interaction between DNMT and MARS2 can moderatly affect the drug-metabolizing process of Methionine-tRNA ligase mitochondrial. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases | |||||
| ICD-11: 5A61 Pituitary gland hypofunction | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Chordoma | Significant hypomethylation | |||
| Interaction Name | DNMT-MARS2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 2.56E-04; delta-beta: -5.06E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the MARS2 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Methionine-tRNA ligase mitochondrial. As a result, the interaction between DNMT and MARS2 can significantly affect the drug-metabolizing process of Methionine-tRNA ligase mitochondrial. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 5B81 Obesity | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Obesity | Significant hypomethylation | |||
| Interaction Name | DNMT-MARS2 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 6.44E-08; delta-beta: -8.74E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the MARS2 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Methionine-tRNA ligase mitochondrial. As a result, the interaction between DNMT and MARS2 can significantly affect the drug-metabolizing process of Methionine-tRNA ligase mitochondrial. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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