Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0188) | |||||
|---|---|---|---|---|---|
| DME Name | Peptide methionine sulfoxide reductase (MSRA), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 1.8.4.11 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 4 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-MSRA interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 3.63E-09; delta-beta: -2.47E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the MSRA gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Peptide methionine sulfoxide reductase. As a result, the interaction between DNMT and MSRA can moderatly affect the drug-metabolizing process of Peptide methionine sulfoxide reductase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Brain neuroepithelial tumour | Significant hypomethylation | |||
| Interaction Name | DNMT-MSRA interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 2.43E-05; delta-beta: -3.88E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the MSRA gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Peptide methionine sulfoxide reductase. As a result, the interaction between DNMT and MSRA can significantly affect the drug-metabolizing process of Peptide methionine sulfoxide reductase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | RELA YAP fusion ependymoma | Significant hypomethylation | |||
| Interaction Name | DNMT-MSRA interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 2.94E-20; delta-beta: -3.94E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the MSRA gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Peptide methionine sulfoxide reductase. As a result, the interaction between DNMT and MSRA can significantly affect the drug-metabolizing process of Peptide methionine sulfoxide reductase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Atypical teratoid/rhabdoid tumour | Significant hypermethylation | |||
| Interaction Name | DNMT-MSRA interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 7.59E-03; delta-beta: 4.96E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the MSRA gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Peptide methionine sulfoxide reductase. As a result, the interaction between DNMT and MSRA can significantly affect the drug-metabolizing process of Peptide methionine sulfoxide reductase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2D50 Brain cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Posterior fossa ependymoma | Significant hypomethylation | |||
| Interaction Name | DNMT-MSRA interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 3.46E-41; delta-beta: -4.59E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the MSRA gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Peptide methionine sulfoxide reductase. As a result, the interaction between DNMT and MSRA can significantly affect the drug-metabolizing process of Peptide methionine sulfoxide reductase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2E06 Prostate cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer metastasis | Significant hypomethylation | |||
| Interaction Name | DNMT-MSRA interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 3.67E-03; delta-beta: -5.27E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the MSRA gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Peptide methionine sulfoxide reductase. As a result, the interaction between DNMT and MSRA can significantly affect the drug-metabolizing process of Peptide methionine sulfoxide reductase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 11 Circulatory system diseases | |||||
| ICD-11: BD51 Arterial aneurysm | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Arterial aneurysm | Significant hypermethylation | |||
| Interaction Name | DNMT-MSRA interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.86E-03; delta-beta: 7.15E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the MSRA gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Peptide methionine sulfoxide reductase. As a result, the interaction between DNMT and MSRA can significantly affect the drug-metabolizing process of Peptide methionine sulfoxide reductase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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