Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0189)
DME Name	S-adenosylmethionine synthase 1 (MAT1A), Homo sapiens	DME Info
UniProt ID	METK1_HUMAN
EC Number	EC: 2.5.1.6 (Click to Show/Hide the Complete EC Tree) Transferase Alkyl/aryl transferase Alkyl/aryl transferase EC: 2.5.1.6
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
ICD Disease Classification 02 Neoplasms
ICD-11: 2B30 Lymphoma		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Lymphoma		Significant hypomethylation
Interaction Name	DNMT-MAT1A interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 8.41E-10; delta-beta: -3.97E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the MAT1A gene, which leads to a significantly increased expression of the drug-metabolizing enzyme S-adenosylmethionine synthase 1. As a result, the interaction between DNMT and MAT1A can significantly affect the drug-metabolizing process of S-adenosylmethionine synthase 1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2C10 Pancreatic adenocarcinoma		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Pancreatic adenocarcinoma		Significant hypomethylation
Interaction Name	DNMT-MAT1A interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 2.94E-02; delta-beta: -3.71E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the MAT1A gene, which leads to a significantly increased expression of the drug-metabolizing enzyme S-adenosylmethionine synthase 1. As a result, the interaction between DNMT and MAT1A can significantly affect the drug-metabolizing process of S-adenosylmethionine synthase 1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue adjacent to the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data of patients in the normal section of the tissue adjacent to the disease section Download DME methylation data in the tissue of healthy individual
ICD-11: 2C12 Liver cancer		Click to Show/Hide the Full List of HOSPPI: 5 HOSPPI
Non-coding RNA regulation
hsa-miR-485-3p		Liver cancer		Suppression
miRBase ID	MIMAT0002176
Interaction Name	hsa-miR-485-3p--MAT1A regulation				[2]
Studied Cell Lines	Hep3B and HepG2 cell lines
Description	hsa-miR-485-3p is reported to suppress MAT1A mRNA translation by binding to the 3' untranslated region (3'UTR) of MAT1A mRNA, which leads to a decreased expression of the drug-metabolizing enzyme S-adenosylmethionine synthase 1.
hsa-miR-495-3p		Liver cancer		Suppression
miRBase ID	MIMAT0002817
Interaction Name	hsa-miR-495-3p--MAT1A regulation				[2]
Studied Cell Lines	Hep3B and HepG2 cell lines
Description	hsa-miR-495-3p is reported to suppress MAT1A mRNA translation by binding to the 3' untranslated region (3'UTR) of MAT1A mRNA, which leads to a decreased expression of the drug-metabolizing enzyme S-adenosylmethionine synthase 1.
hsa-miR-664a-3p		Liver cancer		Suppression
miRBase ID	MIMAT0005949
Interaction Name	hsa-miR-664a-3p--MAT1A regulation				[2]
Studied Cell Lines	Hep3B and HepG2 cell lines
Description	hsa-miR-664a-3p is reported to suppress MAT1A mRNA translation by binding to the 3' untranslated region (3'UTR) of MAT1A mRNA, which leads to a decreased expression of the drug-metabolizing enzyme S-adenosylmethionine synthase 1.
Histone modification
Histone deacetylases (HDACs)		Liver cancer		Repression
Uniprot ID	HDAC1_HUMAN
Interaction Name	HDACs-MAT1A interaction				[1]
Studied Cell Lines	HepG2 cell line
Description	Histone deacetylases (HDACs) are reported to deacetylate the MAT1A gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme S-adenosylmethionine synthase 1. As a result, the interaction between HDACs and MAT1A can inhibit the drug-metabolizing process of S-adenosylmethionine synthase 1.
DNA methylation
DNA methyltransferase (DNMT)		Liver cancer		Moderate hypomethylation
Interaction Name	DNMT-MAT1A interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 5.83E-05; delta-beta: -2.15E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the MAT1A gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme S-adenosylmethionine synthase 1. As a result, the interaction between DNMT and MAT1A can moderatly affect the drug-metabolizing process of S-adenosylmethionine synthase 1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue adjacent to the diseased tissue of patients DME methylation in the normal tissue of healthy individuals DME methylation in tissue other than the diseased tissue of patients
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data of patients in the normal section of the tissue adjacent to the disease section Download DME methylation data in the tissue of healthy individual Download DME methylation data in the tissue of the other disease section
ICD-11: 2C25 Lung cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Lung cancer		Moderate hypomethylation
Interaction Name	DNMT-MAT1A interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 3.67E-21; delta-beta: -2.64E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the MAT1A gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme S-adenosylmethionine synthase 1. As a result, the interaction between DNMT and MAT1A can moderatly affect the drug-metabolizing process of S-adenosylmethionine synthase 1.
The Methylation Level of Disease Section Compare with the Other Disease Section	Moderate hypomethylation p-value: 1.68E-12; delta-beta: -2.40E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the MAT1A gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme S-adenosylmethionine synthase 1. As a result, the interaction between DNMT and MAT1A can moderatly affect the drug-metabolizing process of S-adenosylmethionine synthase 1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals DME methylation in tissue other than the diseased tissue of patients
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual Download DME methylation data in the tissue of the other disease section
ICD-11: 2C90 Renal cell carcinoma		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Renal cell carcinoma		Significant hypermethylation
Interaction Name	DNMT-MAT1A interaction
The Methylation Level of Disease Section Compare with the Other Disease Section	Significant hypermethylation p-value: 1.95E-03; delta-beta: 8.85E-02
Description	DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the MAT1A gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme S-adenosylmethionine synthase 1. As a result, the interaction between DNMT and MAT1A can significantly affect the drug-metabolizing process of S-adenosylmethionine synthase 1.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals DME methylation in tissue other than the diseased tissue of patients
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual Download DME methylation data in the tissue of the other disease section

References
1	Liver-specific methionine adenosyltransferase MAT1A gene expression is associated with a specific pattern of promoter methylation and histone acetylation: implications for MAT1A silencing during transformation. FASEB J. 2000 Jan;14(1):95-102.
2	MicroRNAs regulate methionine adenosyltransferase 1A expression in hepatocellular carcinoma. J Clin Invest. 2013 Jan;123(1):285-98.

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