Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0190)
DME Name S-adenosylmethionine synthase 2 (MAT2A), Homo sapiens DME Info
UniProt ID
METK2_HUMAN
EC Number    EC: 2.5.1.6     (Click to Show/Hide the Complete EC Tree)
Transferase
Alkyl/aryl transferase
Alkyl/aryl transferase
EC: 2.5.1.6
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification Healthy
               ICD-11: Healthy Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Histone modification
                            Histone deacetylases (HDACs) Health Repression
Uniprot ID
HDAC1_HUMAN
Interaction Name HDACs-MAT2A interaction [1]
Studied Cell Lines Human hepatocytes
Description Histone deacetylases (HDACs) are reported to deacetylate the MAT2A gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme S-adenosylmethionine synthase 2. As a result, the interaction between HDACs and MAT2A can inhibit the drug-metabolizing process of S-adenosylmethionine synthase 2.
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2C12 Liver cancer Click to Show/Hide the Full List of HOSPPI:        6 HOSPPI
                     Transcription-factor regulation
                            Nuclear factor kappa-B p105 (NFKB1) Liver cancer Activation
Uniprot ID
NFKB1_HUMAN
Interaction Name NFKB1-MAT2A interaction [3]
Studied Cell Lines HepG2 cell line
Ensembl ID
ENSG00000109320
Description Nuclear factor kappa-B p105 (NFKB1) is reported to activate the transcription of MAT2A gene, which leads to an increased expression of the drug-metabolizing enzyme S-adenosylmethionine synthase 2. As a result, the interaction between NFKB1 and MAT2A can activate the drug-metabolizing process of S-adenosylmethionine synthase 2.
                            Proto-oncogene c-Myb (MYB) Liver cancer Activation
Uniprot ID
MYB_HUMAN
Interaction Name MYB-MAT2A interaction [4]
Studied Cell Lines HCC and HepG2 cell lines
Ensembl ID
ENSG00000118513
Description Proto-oncogene c-Myb (MYB) is reported to activate the transcription of MAT2A gene, which leads to an increased expression of the drug-metabolizing enzyme S-adenosylmethionine synthase 2. As a result, the interaction between MYB and MAT2A can activate the drug-metabolizing process of S-adenosylmethionine synthase 2.
                            Transcription factor AP-1 (JUN) Liver cancer Activation
Uniprot ID
JUN_HUMAN
Interaction Name JUN-MAT2A interaction [3]
Studied Cell Lines HepG2 cell line
Ensembl ID
ENSG00000177606
Description Transcription factor AP-1 (JUN) is reported to activate the transcription of MAT2A gene, which leads to an increased expression of the drug-metabolizing enzyme S-adenosylmethionine synthase 2. As a result, the interaction between JUN and MAT2A can activate the drug-metabolizing process of S-adenosylmethionine synthase 2.
                            Transcription factor p65 (RELA) Liver cancer Activation
Uniprot ID
TF65_HUMAN
Interaction Name RELA-MAT2A interaction [3]
Studied Cell Lines HepG2 cell line
Ensembl ID
ENSG00000173039
Description Transcription factor p65 (RELA) is reported to activate the transcription of MAT2A gene, which leads to an increased expression of the drug-metabolizing enzyme S-adenosylmethionine synthase 2. As a result, the interaction between RELA and MAT2A can activate the drug-metabolizing process of S-adenosylmethionine synthase 2.
                            Transcription factor Sp1 (SP1) Liver cancer Activation
Uniprot ID
SP1_HUMAN
Interaction Name SP1-MAT2A interaction [4]
Studied Cell Lines HCC and HepG2 cell lines
Ensembl ID
ENSG00000185591
Description Transcription factor Sp1 (SP1) is reported to activate the transcription of MAT2A gene, which leads to an increased expression of the drug-metabolizing enzyme S-adenosylmethionine synthase 2. As a result, the interaction between SP1 and MAT2A can activate the drug-metabolizing process of S-adenosylmethionine synthase 2.
                     Non-coding RNA regulation
                            hsa-miR-21-3p Liver cancer Suppression
miRBase ID
MIMAT0004494
Interaction Name hsa-miR-21-3p--MAT2A regulation [2]
Studied Cell Lines HepG2 cell line
Description hsa-miR-21-3p is reported to suppress MAT2A mRNA translation by binding to the 3' untranslated region (3'UTR) of MAT2A mRNA, which leads to a decreased expression of the drug-metabolizing enzyme S-adenosylmethionine synthase 2.
               ICD-11: 2C60 Breast cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Non-coding RNA regulation
                            hsa-miR-146b-3p Breast cancer Suppression
miRBase ID
MIMAT0004766
Interaction Name hsa-miR-146b-3p--MAT2A regulation [5]
Studied Cell Lines MCF-7 and MDA-MB-231 cell lines
Description hsa-miR-146b-3p is reported to suppress MAT2A mRNA translation by binding to the 3' untranslated region (3'UTR) of MAT2A mRNA, which leads to a decreased expression of the drug-metabolizing enzyme S-adenosylmethionine synthase 2.
References
1 Role of promoter methylation in increased methionine adenosyltransferase 2A expression in human liver cancer. Am J Physiol Gastrointest Liver Physiol. 2001 Feb;280(2):G184-90.
2 MicroRNA-21-3p, a berberine-induced miRNA, directly down-regulates human methionine adenosyltransferases 2A and 2B and inhibits hepatoma cell growth. PLoS One. 2013 Sep 30;8(9):e75628.
3 Induction of human methionine adenosyltransferase 2A expression by tumor necrosis factor alphaRole of NF-kappa B and AP-1. J Biol Chem. 2003 Dec 19;278(51):50887-96.
4 The role of c-Myb and Sp1 in the up-regulation of methionine adenosyltransferase 2A gene expression in human hepatocellular carcinoma. FASEB J. 2001 Jul;15(9):1507-16.
5 Induction of methionine adenosyltransferase 2A in tamoxifen-resistant breast cancer cells. Oncotarget. 2016 Mar 22;7(12):13902-16.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.