Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0191)
DME Name	Folylpolyglutamate synthase (FPGS), Homo sapiens	DME Info
UniProt ID	FOLC_HUMAN
EC Number	EC: 6.3.2.17 (Click to Show/Hide the Complete EC Tree) Ligase Carbon-nitrogen ligase Peptide synthase EC: 6.3.2.17
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
ICD Disease Classification 02 Neoplasms
ICD-11: 2A00 Brain cancer		Click to Show/Hide the Full List of HOSPPI: 2 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Brain neuroblastoma		Moderate hypomethylation
Interaction Name	DNMT-FPGS interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 1.96E-17; delta-beta: -2.12E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the FPGS gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Folylpolyglutamate synthase. As a result, the interaction between DNMT and FPGS can moderatly affect the drug-metabolizing process of Folylpolyglutamate synthase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
DNA methyltransferase (DNMT)		Cerebellar liponeurocytoma		Significant hypomethylation
Interaction Name	DNMT-FPGS interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 7.78E-08; delta-beta: -3.59E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the FPGS gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Folylpolyglutamate synthase. As a result, the interaction between DNMT and FPGS can significantly affect the drug-metabolizing process of Folylpolyglutamate synthase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2B33 Acute lymphoblastic leukemia		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Histone modification
Histone deacetylases (HDACs)		Acute lymphoblastic leukemia		Repression
Uniprot ID	HDAC1_HUMAN
Interaction Name	HDACs-FPGS interaction				[1]
Studied Cell Lines	T-ALL cell line
Description	Histone deacetylases (HDACs) are reported to deacetylate the FPGS gene and thereby repress the transcriptional activity of the drug-metabolizing enzyme Folylpolyglutamate synthase. As a result, the interaction between HDACs and FPGS can inhibit the drug-metabolizing process of Folylpolyglutamate synthase.
ICD-11: 2B71 Gastric cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Gastric cancer		Moderate hypermethylation
Interaction Name	DNMT-FPGS interaction
The Methylation Level of Disease Section Compare with the Adjacent Tissue	Moderate hypermethylation p-value: 9.23E-03; delta-beta: 2.74E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the FPGS gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Folylpolyglutamate synthase. As a result, the interaction between DNMT and FPGS can moderatly affect the drug-metabolizing process of Folylpolyglutamate synthase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue adjacent to the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data of patients in the normal section of the tissue adjacent to the disease section Download DME methylation data in the tissue of healthy individual
ICD-11: 2D50 Brain cancer metastasis		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Posterior fossa ependymoma		Moderate hypomethylation
Interaction Name	DNMT-FPGS interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 2.35E-60; delta-beta: -2.22E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the FPGS gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Folylpolyglutamate synthase. As a result, the interaction between DNMT and FPGS can moderatly affect the drug-metabolizing process of Folylpolyglutamate synthase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD-11: 2F7C Connective tissue cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Hemangioblastoma		Moderate hypomethylation
Interaction Name	DNMT-FPGS interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Moderate hypomethylation p-value: 6.04E-10; delta-beta: -2.27E-01
Description	DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the FPGS gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Folylpolyglutamate synthase. As a result, the interaction between DNMT and FPGS can moderatly affect the drug-metabolizing process of Folylpolyglutamate synthase.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual

References
1	Histone deacetylase inhibitors induce FPGS mRNA expression and intracellular accumulation of long-chain methotrexate polyglutamates in childhood acute lymphoblastic leukemia: implications for combination therapy. Leukemia. 2010 Mar;24(3):552-62.

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