Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0193) | |||||
|---|---|---|---|---|---|
| DME Name | Arylsulfatase A (ARSA), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 3.1.6.8 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2C12 Liver cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Liver cancer | Moderate hypermethylation | |||
| Interaction Name | DNMT-ARSA interaction | ||||
| The Methylation Level of Disease Section Compare with the Other Disease Section | Moderate hypermethylation p-value: 4.67E-02; delta-beta: 2.02E-02 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the ARSA gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Arylsulfatase A. As a result, the interaction between DNMT and ARSA can moderatly affect the drug-metabolizing process of Arylsulfatase A. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue adjacent to the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
DME methylation in tissue other than the diseased tissue of patients
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
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