Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0194)
DME Name Choline phosphatase 1 (PLD1), Homo sapiens DME Info
UniProt ID
PLD1_HUMAN
EC Number    EC: 3.1.4.4     (Click to Show/Hide the Complete EC Tree)
Hydrolases
Ester bond hydrolase
Phosphoric diester hydrolase
EC: 3.1.4.4
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification Healthy
               ICD-11: Healthy Click to Show/Hide the Full List of HOSPPI:        2 HOSPPI
                     Oligomerization
                            CDC42 small effector 1 (CDC42SE1) Health Heterooligomer
Uniprot ID
C42S1_HUMAN
Interaction Name CDC42SE1-PLD1 heterooligomerization [1]
Studied Cell Lines Sf9 insect cell line
Description CDC42 small effector 1 (CDC42SE1) is reported to heterooligomerize with the PLD1 gene, which leads to activation of the drug-metabolizing enzyme Choline phosphatase 1. As a result, the interaction between CDC42SE1 and PLD1 can activate the drug-metabolizing process of Choline phosphatase 1.
                            Ras-related Ral-A (RALA) Health Heterooligomer
Uniprot ID
RALA_HUMAN
Interaction Name RALA-PLD1 heterooligomerization [2]
Studied Cell Lines Pansorbin cell line
Description Ras-related Ral-A (RALA) is reported to heterooligomerize with the PLD1 protein, which leads to activation of the drug-metabolizing enzyme Choline phosphatase 1. As a result, the interaction between RALA and PLD1 can activate the drug-metabolizing process of Choline phosphatase 1.
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2B51 Osteosarcoma Click to Show/Hide the Full List of HOSPPI:        2 HOSPPI
                     Transcription-factor regulation
                            Catenin beta-1 (CTNNB1) Osteosarcoma Activation
Uniprot ID
CTNB1_HUMAN
Interaction Name CTNNB1-PLD1 interaction [3]
Studied Cell Lines HOS cell line
Description Catenin beta-1 (CTNNB1) is reported to activate the transcription of PLD1 gene, which leads to an increased expression of the drug-metabolizing enzyme Choline phosphatase 1. As a result, the interaction between CTNNB1 and PLD1 can activate the drug-metabolizing process of Choline phosphatase 1.
                            Transcription factor 4 (TCF4) Osteosarcoma Activation
Uniprot ID
ITF2_HUMAN
Interaction Name TCF4-PLD1 interaction [3]
Studied Cell Lines HOS cell line
Ensembl ID
ENSG00000196628
Description Transcription factor 4 (TCF4) is reported to activate the transcription of PLD1 gene, which leads to an increased expression of the drug-metabolizing enzyme Choline phosphatase 1. As a result, the interaction between TCF4 and PLD1 can activate the drug-metabolizing process of Choline phosphatase 1.
               ICD-11: 2B71 Gastric cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Non-coding RNA regulation
                            hsa-miR-638 Gastric cancer Suppression
miRBase ID
MIMAT0003308
Interaction Name hsa-miR-638--PLD1 regulation [4]
Studied Cell Lines MKN-45 and SGC-7901 cell lines
Description hsa-miR-638 is reported to suppress PLD1 mRNA translation by binding to the 3' untranslated region (3'UTR) of PLD1 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Choline phosphatase 1.
               ICD-11: 2B90 Colorectal cancer Click to Show/Hide the Full List of HOSPPI:        2 HOSPPI
                     Transcription-factor regulation
                            Catenin beta-1 (CTNNB1) Colorectal cancer Activation
Uniprot ID
CTNB1_HUMAN
Interaction Name CTNNB1-PLD1 interaction [3]
Studied Cell Lines HCT116 and SW480 cell lines
Description Catenin beta-1 (CTNNB1) is reported to activate the transcription of PLD1 gene, which leads to an increased expression of the drug-metabolizing enzyme Choline phosphatase 1. As a result, the interaction between CTNNB1 and PLD1 can activate the drug-metabolizing process of Choline phosphatase 1.
                            Transcription factor 4 (TCF4) Colorectal cancer Activation
Uniprot ID
ITF2_HUMAN
Interaction Name TCF4-PLD1 interaction [3]
Studied Cell Lines HCT116 and SW480 cell lines
Ensembl ID
ENSG00000196628
Description Transcription factor 4 (TCF4) is reported to activate the transcription of PLD1 gene, which leads to an increased expression of the drug-metabolizing enzyme Choline phosphatase 1. As a result, the interaction between TCF4 and PLD1 can activate the drug-metabolizing process of Choline phosphatase 1.
               ICD-11: 2C12 Liver cancer Click to Show/Hide the Full List of HOSPPI:        2 HOSPPI
                     Transcription-factor regulation
                            Catenin beta-1 (CTNNB1) Liver cancer Activation
Uniprot ID
CTNB1_HUMAN
Interaction Name CTNNB1-PLD1 interaction [3]
Studied Cell Lines SNU475 and SNU-C5 cell lines
Description Catenin beta-1 (CTNNB1) is reported to activate the transcription of PLD1 gene, which leads to an increased expression of the drug-metabolizing enzyme Choline phosphatase 1. As a result, the interaction between CTNNB1 and PLD1 can activate the drug-metabolizing process of Choline phosphatase 1.
                            Transcription factor 4 (TCF4) Liver cancer Activation
Uniprot ID
ITF2_HUMAN
Interaction Name TCF4-PLD1 interaction [3]
Studied Cell Lines SNU475 and SNU-C5 cell lines
Ensembl ID
ENSG00000196628
Description Transcription factor 4 (TCF4) is reported to activate the transcription of PLD1 gene, which leads to an increased expression of the drug-metabolizing enzyme Choline phosphatase 1. As a result, the interaction between TCF4 and PLD1 can activate the drug-metabolizing process of Choline phosphatase 1.
               ICD-11: 2C60 Breast cancer Click to Show/Hide the Full List of HOSPPI:        3 HOSPPI
                     Transcription-factor regulation
                            Catenin beta-1 (CTNNB1) Breast cancer Activation
Uniprot ID
CTNB1_HUMAN
Interaction Name CTNNB1-PLD1 interaction [3]
Studied Cell Lines MDA-MB 231; MDA-MB 361; SK-BR3 cell lines
Description Catenin beta-1 (CTNNB1) is reported to activate the transcription of PLD1 gene, which leads to an increased expression of the drug-metabolizing enzyme Choline phosphatase 1. As a result, the interaction between CTNNB1 and PLD1 can activate the drug-metabolizing process of Choline phosphatase 1.
                            Transcription factor 4 (TCF4) Breast cancer Activation
Uniprot ID
ITF2_HUMAN
Interaction Name TCF4-PLD1 interaction [3]
Studied Cell Lines MDA-MB 231; MDA-MB 361; SK-BR3 cell lines
Ensembl ID
ENSG00000196628
Description Transcription factor 4 (TCF4) is reported to activate the transcription of PLD1 gene, which leads to an increased expression of the drug-metabolizing enzyme Choline phosphatase 1. As a result, the interaction between TCF4 and PLD1 can activate the drug-metabolizing process of Choline phosphatase 1.
                     Non-coding RNA regulation
                            hsa-miR-182-5p Breast cancer Suppression
miRBase ID
MIMAT0000259
Interaction Name hsa-miR-182-5p--PLD1 regulation [5]
Studied Cell Lines MCF-7 and BT-474 cell lines
Description hsa-miR-182-5p is reported to suppress PLD1 mRNA translation by binding to the 3' untranslated region (3'UTR) of PLD1 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Choline phosphatase 1.
               ICD-11: 2C82 Prostate cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Prostate cancer Moderate hypomethylation
Interaction Name DNMT-PLD1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Moderate hypomethylation
p-value: 9.15E-08; delta-beta: -2.20E-01
Description DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the PLD1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Choline phosphatase 1. As a result, the interaction between DNMT and PLD1 can moderatly affect the drug-metabolizing process of Choline phosphatase 1.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples
Download DME methylation data of patients in the disease section of the tissue
Download DME methylation data in the tissue of healthy individual
               ICD-11: 2E06 Prostate cancer metastasis Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     DNA methylation
                            DNA methyltransferase (DNMT) Prostate cancer metastasis Significant hypomethylation
Interaction Name DNMT-PLD1 interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue Significant hypomethylation
p-value: 1.75E-04; delta-beta: -3.96E-01
Description DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the PLD1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Choline phosphatase 1. As a result, the interaction between DNMT and PLD1 can significantly affect the drug-metabolizing process of Choline phosphatase 1.
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples
Download DME methylation data of patients in the disease section of the tissue
Download DME methylation data in the tissue of healthy individual
References
1 Activation of phospholipase D1 by Cdc42 requires the Rho insert region. J Biol Chem. 2000 May 26;275(21):15665-8.
2 Activation of phospholipase D1 by direct interaction with ADP-ribosylation factor 1 and RalA. FEBS Lett. 1998 Jul 3;430(3):231-5.
3 Phospholipase D1 drives a positive feedback loop to reinforce the Wnt/beta-catenin/TCF signaling axis. Cancer Res. 2010 May 15;70(10):4233-42.
4 MicroRNA-638 inhibits cell proliferation by targeting phospholipase D1 in human gastric carcinoma. Protein Cell. 2015 Sep;6(9):680-688.
5 A Repertoire of MicroRNAs Regulates Cancer Cell Starvation by Targeting Phospholipase D in a Feedback Loop That Operates Maximally in Cancer Cells. Mol Cell Biol. 2016 Jan 19;36(7):1078-89.

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