Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0195)
DME Name	Phosphodiesterase 5A (PDE5A), Homo sapiens	DME Info
UniProt ID	PDE5A_HUMAN
EC Number	EC: 3.1.4.35 (Click to Show/Hide the Complete EC Tree) Hydrolases Ester bond hydrolase Phosphoric diester hydrolase EC: 3.1.4.35
Lineage	Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) Kingdom: Metazoa Phylum: Chordata Class: Mammalia Order: Primates Family: Hominidae Genus: Homo Species: Homo sapiens
Interactome

Disease Specific Interactions between Host Protein and DME (HOSPPI)
ICD Disease Classification 02 Neoplasms
ICD-11: 2C12 Liver cancer		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Liver cancer		Moderate hypermethylation
Interaction Name	DNMT-PDE5A interaction
The Methylation Level of Disease Section Compare with the Other Disease Section	Moderate hypermethylation p-value: 1.20E-02; delta-beta: 2.40E-02
Description	DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the PDE5A gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Phosphodiesterase 5A. As a result, the interaction between DNMT and PDE5A can moderatly affect the drug-metabolizing process of Phosphodiesterase 5A.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue adjacent to the diseased tissue of patients DME methylation in the normal tissue of healthy individuals DME methylation in tissue other than the diseased tissue of patients
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data of patients in the normal section of the tissue adjacent to the disease section Download DME methylation data in the tissue of healthy individual Download DME methylation data in the tissue of the other disease section
ICD-11: 2C30 Melanoma		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
Transcription-factor regulation
Octamer-binding protein 7 (POU3F2)		Melanoma		Repression
Uniprot ID	PO3F2_HUMAN
Interaction Name	POU3F2-PDE5A interaction				[1]
Studied Cell Lines	WM266.4, A375P, A375M2, Skeml28, Skmel24, Colo829, Skeml5, Skmel13, MEL-HO, 501mel and 4599 cell lines
Ensembl ID	ENSG00000184486
Description	Octamer-binding protein 7 (POU3F2) is reported to repress the transcription of PDE5A gene, which leads to a decreased expression of the drug-metabolizing enzyme Phosphodiesterase 5A. As a result, the interaction between POU3F2 and PDE5A can repress the drug-metabolizing process of Phosphodiesterase 5A.
ICD-11: 2E06 Prostate cancer metastasis		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Prostate cancer metastasis		Significant hypomethylation
Interaction Name	DNMT-PDE5A interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 1.15E-02; delta-beta: -3.36E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the PDE5A gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Phosphodiesterase 5A. As a result, the interaction between DNMT and PDE5A can significantly affect the drug-metabolizing process of Phosphodiesterase 5A.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual
ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases
ICD-11: 5B81 Obesity		Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI
DNA methylation
DNA methyltransferase (DNMT)		Obesity		Significant hypomethylation
Interaction Name	DNMT-PDE5A interaction
The Methylation Level of Disease Section Compare with the Healthy Individual Tissue	Significant hypomethylation p-value: 2.57E-08; delta-beta: -3.56E-01
Description	DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the PDE5A gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Phosphodiesterase 5A. As a result, the interaction between DNMT and PDE5A can significantly affect the drug-metabolizing process of Phosphodiesterase 5A.
DME methylation in the diseased tissue of patients DME methylation in the normal tissue of healthy individuals
Violin Diagram of DME Disease-specific Methylation Level			Click to View the Clearer Original Diagram
Download DME methylation barchart for all samples Download DME methylation data of patients in the disease section of the tissue Download DME methylation data in the tissue of healthy individual

References
1	Oncogenic BRAF induces melanoma cell invasion by downregulating the cGMP-specific phosphodiesterase PDE5A. Cancer Cell. 2011 Jan 18;19(1):45-57.

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