Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0197) | |||||
|---|---|---|---|---|---|
| DME Name | Aldo-keto reductase 1C1 (AKR1C1), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 1.1.1.149 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 3 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Medulloblastoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-AKR1C1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 8.22E-42; delta-beta: -2.68E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the AKR1C1 gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Aldo-keto reductase 1C1. As a result, the interaction between DNMT and AKR1C1 can moderatly affect the drug-metabolizing process of Aldo-keto reductase 1C1. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
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Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Melanocytoma | Moderate hypermethylation | |||
| Interaction Name | DNMT-AKR1C1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 6.59E-07; delta-beta: 2.32E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the AKR1C1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Aldo-keto reductase 1C1. As a result, the interaction between DNMT and AKR1C1 can moderatly affect the drug-metabolizing process of Aldo-keto reductase 1C1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Atypical teratoid/rhabdoid tumour | Moderate hypermethylation | |||
| Interaction Name | DNMT-AKR1C1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 9.20E-14; delta-beta: 2.22E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the AKR1C1 gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Aldo-keto reductase 1C1. As a result, the interaction between DNMT and AKR1C1 can moderatly affect the drug-metabolizing process of Aldo-keto reductase 1C1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2A60 Acute myeloid leukemia | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Acute myeloid leukemia | Significant hypomethylation | |||
| Interaction Name | DNMT-AKR1C1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 3.69E-05; delta-beta: -3.43E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the AKR1C1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Aldo-keto reductase 1C1. As a result, the interaction between DNMT and AKR1C1 can significantly affect the drug-metabolizing process of Aldo-keto reductase 1C1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C82 Prostate cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer | Significant hypermethylation | |||
| Interaction Name | DNMT-AKR1C1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 4.24E-06; delta-beta: 3.13E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the AKR1C1 gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Aldo-keto reductase 1C1. As a result, the interaction between DNMT and AKR1C1 can significantly affect the drug-metabolizing process of Aldo-keto reductase 1C1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD Disease Classification 05 Endocrine/nutritional/metabolic diseases | |||||
| ICD-11: 5B81 Obesity | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Obesity | Significant hypomethylation | |||
| Interaction Name | DNMT-AKR1C1 interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 3.13E-23; delta-beta: -4.59E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the AKR1C1 gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Aldo-keto reductase 1C1. As a result, the interaction between DNMT and AKR1C1 can significantly affect the drug-metabolizing process of Aldo-keto reductase 1C1. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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