Details of Host Protein-DME Interaction (HOSPPI)
| General Information of Drug-Metabolizing Enzyme (DME ID: DME0200) | |||||
|---|---|---|---|---|---|
| DME Name | Bile acid-CoA thioesterase (BAAT), Homo sapiens | DME Info | |||
| UniProt ID | |||||
| EC Number | EC: 2.3.1.65 (Click to Show/Hide the Complete EC Tree) | ||||
| Lineage | Species: Homo sapiens (Click to Show/Hide the Complete Species Lineage) | ||||
| Interactome | |||||
| Disease Specific Interactions between Host Protein and DME (HOSPPI) | |||||
|---|---|---|---|---|---|
| ICD Disease Classification 02 Neoplasms | |||||
| ICD-11: 2A00 Brain cancer | Click to Show/Hide the Full List of HOSPPI: 6 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Brain neuroblastoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-BAAT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.30E-08; delta-beta: -2.39E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the BAAT gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Bile acid-CoA thioesterase. As a result, the interaction between DNMT and BAAT can moderatly affect the drug-metabolizing process of Bile acid-CoA thioesterase. | ||||
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DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
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| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Brain neuroepithelial tumour | Significant hypomethylation | |||
| Interaction Name | DNMT-BAAT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 1.18E-13; delta-beta: -3.85E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the BAAT gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Bile acid-CoA thioesterase. As a result, the interaction between DNMT and BAAT can significantly affect the drug-metabolizing process of Bile acid-CoA thioesterase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Multilayered rosettes embryonal tumour | Significant hypomethylation | |||
| Interaction Name | DNMT-BAAT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 3.20E-31; delta-beta: -4.74E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the BAAT gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Bile acid-CoA thioesterase. As a result, the interaction between DNMT and BAAT can significantly affect the drug-metabolizing process of Bile acid-CoA thioesterase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Myxopapillary ependymoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-BAAT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 1.89E-08; delta-beta: -2.64E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the BAAT gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Bile acid-CoA thioesterase. As a result, the interaction between DNMT and BAAT can moderatly affect the drug-metabolizing process of Bile acid-CoA thioesterase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | RELA YAP fusion ependymoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-BAAT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 4.11E-13; delta-beta: -2.95E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the BAAT gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Bile acid-CoA thioesterase. As a result, the interaction between DNMT and BAAT can moderatly affect the drug-metabolizing process of Bile acid-CoA thioesterase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| DNA methyltransferase (DNMT) | Atypical teratoid/rhabdoid tumour | Significant hypermethylation | |||
| Interaction Name | DNMT-BAAT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 1.16E-13; delta-beta: 5.78E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the BAAT gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Bile acid-CoA thioesterase. As a result, the interaction between DNMT and BAAT can significantly affect the drug-metabolizing process of Bile acid-CoA thioesterase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C30 Melanoma | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Melanoma | Moderate hypomethylation | |||
| Interaction Name | DNMT-BAAT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypomethylation p-value: 9.16E-06; delta-beta: -2.49E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hypo-methylate the BAAT gene, which leads to a moderatly increased expression of the drug-metabolizing enzyme Bile acid-CoA thioesterase. As a result, the interaction between DNMT and BAAT can moderatly affect the drug-metabolizing process of Bile acid-CoA thioesterase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2C82 Prostate cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer | Moderate hypermethylation | |||
| Interaction Name | DNMT-BAAT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 5.56E-05; delta-beta: 2.64E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the BAAT gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Bile acid-CoA thioesterase. As a result, the interaction between DNMT and BAAT can moderatly affect the drug-metabolizing process of Bile acid-CoA thioesterase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2D50 Brain cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Posterior fossa ependymoma | Significant hypomethylation | |||
| Interaction Name | DNMT-BAAT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypomethylation p-value: 2.14E-38; delta-beta: -3.47E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hypo-methylate the BAAT gene, which leads to a significantly increased expression of the drug-metabolizing enzyme Bile acid-CoA thioesterase. As a result, the interaction between DNMT and BAAT can significantly affect the drug-metabolizing process of Bile acid-CoA thioesterase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2E06 Prostate cancer metastasis | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Prostate cancer metastasis | Significant hypermethylation | |||
| Interaction Name | DNMT-BAAT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Significant hypermethylation p-value: 5.32E-04; delta-beta: 3.30E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to significantly hyper-methylate the BAAT gene, which leads to a significantly decreased expression of the drug-metabolizing enzyme Bile acid-CoA thioesterase. As a result, the interaction between DNMT and BAAT can significantly affect the drug-metabolizing process of Bile acid-CoA thioesterase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
| ICD-11: 2F37 Endocrine gland cancer | Click to Show/Hide the Full List of HOSPPI: 1 HOSPPI | ||||
| DNA methylation | |||||
| DNA methyltransferase (DNMT) | Pituitary adenoma | Moderate hypermethylation | |||
| Interaction Name | DNMT-BAAT interaction | ||||
| The Methylation Level of Disease Section Compare with the Healthy Individual Tissue | Moderate hypermethylation p-value: 1.03E-08; delta-beta: 2.66E-01 | ||||
| Description | DNA methyltransferase (DNMT) is reported to moderatly hyper-methylate the BAAT gene, which leads to a moderatly decreased expression of the drug-metabolizing enzyme Bile acid-CoA thioesterase. As a result, the interaction between DNMT and BAAT can moderatly affect the drug-metabolizing process of Bile acid-CoA thioesterase. | ||||
|
DME methylation in the diseased tissue of patients
DME methylation in the normal tissue of healthy individuals
|
|||||
| Violin Diagram of DME Disease-specific Methylation Level |
|
Click to View the Clearer Original Diagram | |||
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