Details of Host Protein-DME Interaction (HOSPPI)

General Information of Drug-Metabolizing Enzyme (DME ID: DME0201)
DME Name Arachidonate 5-lipoxygenase (ALOX5), Homo sapiens DME Info
UniProt ID
LOX5_HUMAN
EC Number    EC: 1.13.11.34     (Click to Show/Hide the Complete EC Tree)
Oxidoreductase
Oxygen single donor oxidoreductase
Oxygen single donor oxidoreductase
EC: 1.13.11.34
Lineage    Species: Homo sapiens     (Click to Show/Hide the Complete Species Lineage)
Kingdom: Metazoa
Phylum: Chordata
Class: Mammalia
Order: Primates
Family: Hominidae
Genus: Homo
Species: Homo sapiens
Interactome
Disease Specific Interactions between Host Protein and DME (HOSPPI)
      ICD Disease Classification 02 Neoplasms
               ICD-11: 2B33 Acute lymphoblastic leukemia Click to Show/Hide the Full List of HOSPPI:        8 HOSPPI
                     Transcription-factor regulation
                            Methyl-CpG-binding MBD1 (MBD1) Acute lymphoblastic leukemia Repression
Uniprot ID
MBD1_HUMAN
Interaction Name MBD1-ALOX5 interaction [3]
Studied Cell Lines HL-60, U937 and Mono Mac6 cell lines
Ensembl ID
ENSG00000141644
Description Methyl-CpG-binding MBD1 (MBD1) is reported to repress the transcription of ALOX5 gene, which leads to a decreased expression of the drug-metabolizing enzyme Arachidonate 5-lipoxygenase. As a result, the interaction between MBD1 and ALOX5 can repress the drug-metabolizing process of Arachidonate 5-lipoxygenase.
                            Transcription factor Sp1 (SP1) Acute lymphoblastic leukemia Activation
Uniprot ID
SP1_HUMAN
Interaction Name SP1-ALOX5 interaction [4], [3]
Studied Cell Lines MM6, HL-60 and U937 cell lines
Ensembl ID
ENSG00000185591
Description Transcription factor Sp1 (SP1) is reported to activate the transcription of ALOX5 gene, which leads to an increased expression of the drug-metabolizing enzyme Arachidonate 5-lipoxygenase. As a result, the interaction between SP1 and ALOX5 can activate the drug-metabolizing process of Arachidonate 5-lipoxygenase.
                     Non-coding RNA regulation
                            hsa-miR-125b-5p Acute lymphoblastic leukemia Suppression
miRBase ID
MIMAT0000423
Interaction Name hsa-miR-125b-5p--ALOX5 regulation [2]
Studied Cell Lines Mono Mac 6 cell line
Description hsa-miR-125b-5p is reported to suppress ALOX5 mRNA translation by binding to the 3' untranslated region (3'UTR) of ALOX5 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Arachidonate 5-lipoxygenase.
                            hsa-miR-19a-3p Acute lymphoblastic leukemia Suppression
miRBase ID
MIMAT0000073
Interaction Name hsa-miR-19a-3p--ALOX5 regulation [2]
Studied Cell Lines Mono Mac 6 cell line
Description hsa-miR-19a-3p is reported to suppress ALOX5 mRNA translation by binding to the 3' untranslated region (3'UTR) of ALOX5 mRNA, which leads to a decreased expression of the drug-metabolizing enzyme Arachidonate 5-lipoxygenase.
                     Histone modification
                            Histone deacetylase 2 (HDAC2) Acute lymphoblastic leukemia Repression
Uniprot ID
HDAC2_HUMAN
Interaction Name HDAC2-ALOX5 interaction [1]
Studied Cell Lines HL-60, U937 and Mono Mac6 cell lines
Description Histone deacetylase 2 (HDAC2) is reported to deacetylate the ALOX5 gene and thereby represses the transcriptional activity of the drug-metabolizing enzyme Arachidonate 5-lipoxygenase. As a result, the interaction between HDAC2 and ALOX5 can inhibit the drug-metabolizing process of Arachidonate 5-lipoxygenase.
                            Histone deacetylase 2 (HDAC2) Acute lymphoblastic leukemia Repression
Uniprot ID
HDAC2_HUMAN
Interaction Name HDAC2-ALOX5 interaction [1]
Studied Cell Lines HL-60, U937 and Mono Mac6 cell lines
Description Histone deacetylase 2 (HDAC2) is reported to deacetylate the ALOX5 gene and thereby represses the transcriptional activity of the drug-metabolizing enzyme Arachidonate 5-lipoxygenase. As a result, the interaction between HDAC2 and ALOX5 can inhibit the drug-metabolizing process of Arachidonate 5-lipoxygenase.
                            Histone deacetylase 3 (HDAC3) Acute lymphoblastic leukemia Repression
Uniprot ID
HDAC3_HUMAN
Interaction Name HDAC3-ALOX5 interaction [1]
Studied Cell Lines HL-60, U937 and Mono Mac6 cell lines
Description Histone deacetylase 3 (HDAC3) is reported to deacetylate the ALOX5 gene and thereby represses the transcriptional activity of the drug-metabolizing enzyme Arachidonate 5-lipoxygenase. As a result, the interaction between HDAC3 and ALOX5 can inhibit the drug-metabolizing process of Arachidonate 5-lipoxygenase.
                            Histone deacetylase 3 (HDAC3) Acute lymphoblastic leukemia Repression
Uniprot ID
HDAC3_HUMAN
Interaction Name HDAC3-ALOX5 interaction [1]
Studied Cell Lines HL-60, U937 and Mono Mac6 cell lines
Description Histone deacetylase 3 (HDAC3) is reported to deacetylate the ALOX5 gene and thereby represses the transcriptional activity of the drug-metabolizing enzyme Arachidonate 5-lipoxygenase. As a result, the interaction between HDAC3 and ALOX5 can inhibit the drug-metabolizing process of Arachidonate 5-lipoxygenase.
               ICD-11: 2C77 Cervical cancer Click to Show/Hide the Full List of HOSPPI:        1 HOSPPI
                     Transcription-factor regulation
                            Early growth response 1 (EGR1) Cervical cancer Activation
Uniprot ID
EGR1_HUMAN
Interaction Name EGR1-ALOX5 interaction [4]
Studied Cell Lines HeLa cell line
Ensembl ID
ENSG00000120738
Description Early growth response 1 (EGR1) is reported to activate the transcription of ALOX5 gene, which leads to an increased expression of the drug-metabolizing enzyme Arachidonate 5-lipoxygenase. As a result, the interaction between EGR1 and ALOX5 can activate the drug-metabolizing process of Arachidonate 5-lipoxygenase.
References
1 Trichostatin A induces 5-lipoxygenase promoter activity and mRNA expression via inhibition of histone deacetylase 2 and 3. J Cell Mol Med. 2012 Jul;16(7):1461-73.
2 5-lipoxygenase is a direct target of miR-19a-3p and miR-125b-5p. J Immunol. 2015 Feb 15;194(4):1646-53.
3 Role of DNA methylation and methyl-DNA binding proteins in the repression of 5-lipoxygenase promoter activity. Biochim Biophys Acta. 2010 Jan;1801(1):49-57.
4 Naturally occurring mutations in the human 5-lipoxygenase gene promoter that modify transcription factor binding and reporter gene transcription. J Clin Invest. 1997 Mar 1;99(5):1130-7.

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